Download This PaperRegioselective Lithium-Halogen Exchange and Palladium-Catalyzed Cross-Coupling Reactions of 2,4-Dihaloquinolines
Tetrahedron Letters, Vol. 46, pp. 6697-6699, 2005
3 Pages Posted: 23 Jan 2012
Date Written: September 26, 2005
Abstract
Lithium–halogen exchange of 2,4-dibromoquinolines proceeds regioselectively at C-4 and affords 4-substituted quinolines on quenching with electrophiles. Palladium-catalyzed cross-coupling reactions of 2-bromo-4-iodoquinoline provide 4-substituted 2-bromoquinoline derivatives.
Keywords: Lithium-halogen exchange, quinoline
Suggested Citation: Suggested Citation
Nolan, Jason M., Regioselective Lithium-Halogen Exchange and Palladium-Catalyzed
Cross-Coupling Reactions of 2,4-Dihaloquinolines (September 26, 2005). Tetrahedron Letters, Vol. 46, pp. 6697-6699, 2005, Available at SSRN: https://ssrn.com/abstract=1989622
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