Cognitive Interventions Targeting Brain Plasticity in the Prodromal and Early Phases of Schizophrenia

Posted: 31 Mar 2013

See all articles by Melissa R. Fisher

Melissa R. Fisher

University of California, San Francisco (UCSF) - Department of Psychiatry

Rachel Loewy

University of California, San Francisco (UCSF) - Department of Psychiatry

Kate Hardy

University of California, San Francisco (UCSF) - Department of Psychiatry; University of Leeds - Work and Employment Relations

Danielle Schlosser

University of California, San Francisco (UCSF) - Department of Psychiatry

Sophia Vinogradov

University of California, San Francisco (UCSF) - Department of Psychiatry

Date Written: March 2013

Abstract

Several important paradigm shifts have occurred in the field of schizophrenia treatment, including an increased focus on early detection, the development of preemptive interventions, and the view of schizophrenia as a neurodevelopmental disease characterized by decreased efficiency and abnormal connectivity in cortical and subcortical neural networks. In this review, we briefly describe some of the neural impairments that contribute to the development of schizophrenia, with an emphasis on the impact of stress and trauma on cognitively vulnerable neural systems. We then present current data on two behavioral interventions that target these critical risk factors and that aim to preempt the onset of schizophrenia in vulnerable individuals or improve the clinical course in recent-onset schizophrenia: cognitive therapy and computerized cognitive training.

Suggested Citation

Fisher, Melissa R. and Loewy, Rachel and Hardy, Kate and Schlosser, Danielle and Vinogradov, Sophia, Cognitive Interventions Targeting Brain Plasticity in the Prodromal and Early Phases of Schizophrenia (March 2013). Annual Review of Clinical Psychology, Vol. 9, pp. 435-463, 2013, Available at SSRN: https://ssrn.com/abstract=2242313 or http://dx.doi.org/10.1146/annurev-clinpsy-032511-143134

Melissa R. Fisher (Contact Author)

University of California, San Francisco (UCSF) - Department of Psychiatry ( email )

982 Mission St
San Francisco, CA 94103
United States

Rachel Loewy

University of California, San Francisco (UCSF) - Department of Psychiatry

982 Mission St
San Francisco, CA 94103
United States

Kate Hardy

University of California, San Francisco (UCSF) - Department of Psychiatry

982 Mission St
San Francisco, CA 94103
United States

University of Leeds - Work and Employment Relations

Leeds
United Kingdom

Danielle Schlosser

University of California, San Francisco (UCSF) - Department of Psychiatry

982 Mission St
San Francisco, CA 94103
United States

Sophia Vinogradov

University of California, San Francisco (UCSF) - Department of Psychiatry

982 Mission St
San Francisco, CA 94103
United States

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