In Vivo Antidepressant and Anxiolytic Activity of the Methanol Extract of Helianthus Annuus Seeds

International Journal of Innovative and Applied Research (2016), Volume 4, Issue (2): 5-10

6 Pages Posted: 21 Oct 2016

See all articles by Rubab Islam

Rubab Islam

University of Science and Technology Chittagong (USTC) - Department of Pharmacy

Ahmed Tanjimul Islam

Chittagong Medical College & Hospital - Department of Medicine

Kishor Mazumder

University of Science and Technology Chittagong (USTC)

Date Written: 2016

Abstract

The present study was carried out to investigate the antidepressant and anxiolytic activity of methanolic extract of Helianthus annuus seeds in mice model.

Methods: The efficacy of extract (100-200mg/kg) was compared with standard antidepressant drug Imipramine 60 mg/kg and anxiolytic drug diazepam (1mg/kg). Antidepressant activity was done in mice model by tail suspension test and anxiolytic activity was determined both light-dark box test and elevated plus maze test.

Results: The results revealed that the methanol extract of Helianthus annuus seeds showed a significant result in tail suspension test at 100 mg/kg (93 ± 0.47 seconds) and 200 mg/kg (78 ± 1.3 seconds) and moderate result in light-dark box test at 100 mg/kg (63±0.62) and 200 mg/kg (72±0.85), in elevated plus maze test at 100 mg/kg (51± 0.58 seconds) and 200 mg/kg (60±0.62 seconds).

Conclusion: The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models.

Keywords: helianthus annuus, antidepressant activity, anxiolytic activity, mice model

Suggested Citation

Islam, Rubab and Islam, Ahmed Tanjimul and Mazumder, Kishor, In Vivo Antidepressant and Anxiolytic Activity of the Methanol Extract of Helianthus Annuus Seeds (2016). International Journal of Innovative and Applied Research (2016), Volume 4, Issue (2): 5-10 , Available at SSRN: https://ssrn.com/abstract=2856348

Rubab Islam

University of Science and Technology Chittagong (USTC) - Department of Pharmacy ( email )

Chittagong, 4202
Bangladesh

Ahmed Tanjimul Islam (Contact Author)

Chittagong Medical College & Hospital - Department of Medicine ( email )

Chittagong
Bangladesh

Kishor Mazumder

University of Science and Technology Chittagong (USTC)

Chittagong, 4202
Bangladesh

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