In Vivo Antidepressant and Anxiolytic Activity of the Methanol Extract of Helianthus Annuus Seeds
International Journal of Innovative and Applied Research (2016), Volume 4, Issue (2): 5-10
6 Pages Posted: 21 Oct 2016
Date Written: 2016
Abstract
The present study was carried out to investigate the antidepressant and anxiolytic activity of methanolic extract of Helianthus annuus seeds in mice model.
Methods: The efficacy of extract (100-200mg/kg) was compared with standard antidepressant drug Imipramine 60 mg/kg and anxiolytic drug diazepam (1mg/kg). Antidepressant activity was done in mice model by tail suspension test and anxiolytic activity was determined both light-dark box test and elevated plus maze test.
Results: The results revealed that the methanol extract of Helianthus annuus seeds showed a significant result in tail suspension test at 100 mg/kg (93 ± 0.47 seconds) and 200 mg/kg (78 ± 1.3 seconds) and moderate result in light-dark box test at 100 mg/kg (63±0.62) and 200 mg/kg (72±0.85), in elevated plus maze test at 100 mg/kg (51± 0.58 seconds) and 200 mg/kg (60±0.62 seconds).
Conclusion: The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models.
Keywords: helianthus annuus, antidepressant activity, anxiolytic activity, mice model
Suggested Citation: Suggested Citation