Anticonvulsant Effects of Non-Benzodiazepine Bzr Ligand Benzylimidazolylthiadiazolidine in Mice

Science Direct Working Paper No S1574-0331(04)70863-2

5 Pages Posted: 8 Jun 2017 Last revised: 20 Jan 2018

See all articles by Farzin Hadizadeh

Farzin Hadizadeh

Mashhad University of Medical Sciences - Department of Medicinal Chemistry, Faculty of Pharmacy

Hossein Hosseinzadeh

Mashhad University of Medical Sciences - Department of Medicinal Chemistry, Faculty of Pharmacy

Mashallah Mehrabi

Mashhad University of Medical Sciences - Department of Medicinal Chemistry, Faculty of Pharmacy

Date Written: August 2002

Abstract

Benzodiazepine analogs are used as antianxiety, sedative, hypnotic, muscle relaxant and anticonvulsant agents in medicine.The anticonvulsant effects of benzylimidazolylthiadiazolidines, non-benzodiazepine BZR ligands 2a-c were studied in mice in order to identify more potent anticonvulsant agents.The maximal electroshock test was used for assessing antiseizure effects.Diazepam as well as non-benzodiazepine BZR ligands 2b and 2c decreased the duration of tonic seizures and showed a statistically significant anticonvulsant activity in the maximal electroshock test. However, the efficacy of these BZR ligands was lower than diazepam.Results indicate that 2b and may have beneficial effect in grand mal seizures.

Keywords: Diazepam, non-benzodiazepine BZR ligands, anticonvulsant activity

Suggested Citation

Hadizadeh, Farzin and Hosseinzadeh, Hossein and Mehrabi, Mashallah, Anticonvulsant Effects of Non-Benzodiazepine Bzr Ligand Benzylimidazolylthiadiazolidine in Mice (August 2002). Science Direct Working Paper No S1574-0331(04)70863-2, Available at SSRN: https://ssrn.com/abstract=2981228

Farzin Hadizadeh (Contact Author)

Mashhad University of Medical Sciences - Department of Medicinal Chemistry, Faculty of Pharmacy ( email )

P.O. Box 91775
Iran

Hossein Hosseinzadeh

Mashhad University of Medical Sciences - Department of Medicinal Chemistry, Faculty of Pharmacy

P.O. Box 91775
Iran

Mashallah Mehrabi

Mashhad University of Medical Sciences - Department of Medicinal Chemistry, Faculty of Pharmacy

P.O. Box 91775
Iran

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