Electrical Stimulation Can Induce Changes in Dynamics of a Spinal Cord Neuronal Network Cultured on Microelectrode Arrays

Science Direct Working Paper No S1574-034X(04)70405-6

5 Pages Posted: 1 Feb 2018

See all articles by A. Novellino

A. Novellino

University of Genova - Neural and Bioelectronic Technologies Group

M. Chiappalone

University of Genova - Neural and Bioelectronic Technologies Group

A. Vato

University of Genova - Neural and Bioelectronic Technologies Group

M. Bove

University of Genova - Neural and Bioelectronic Technologies Group

S. Martinoia

University of Genova - Department of Experimental Medicine (DIMES)

Date Written: February 2002

Abstract

The spontaneous electrophysiological activity of neural networks seems to play an important role in the Central Nervous System (CNS) developing, subsequent maturation and learning. Learning a new behavior is an exploration process that involves the modulation and the formation of association set between stimuli and responses. Here we analyze how the electrophysiological activity of cultured spinal cord neurons (14 DIV) from the chick embryo is affected by electrical stimulation. Active neurons show a typical high frequency activity pattern called burst. Induced changes in the patterns of electrophysiological activity are described.

Keywords: microelectrode array, spinal cord network, burst activity, electrical stimulation, network dynamics

Suggested Citation

Novellino, A. and Chiappalone, M. and Vato, A. and Bove, M. and Martinoia, S., Electrical Stimulation Can Induce Changes in Dynamics of a Spinal Cord Neuronal Network Cultured on Microelectrode Arrays (February 2002). Science Direct Working Paper No S1574-034X(04)70405-6, Available at SSRN: https://ssrn.com/abstract=3111451

A. Novellino (Contact Author)

University of Genova - Neural and Bioelectronic Technologies Group

Genova
Italy

M. Chiappalone

University of Genova - Neural and Bioelectronic Technologies Group

Genova
Italy

A. Vato

University of Genova - Neural and Bioelectronic Technologies Group

Genova
Italy

M. Bove

University of Genova - Neural and Bioelectronic Technologies Group

Genova
Italy

S. Martinoia

University of Genova - Department of Experimental Medicine (DIMES)

Genova
Italy

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