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The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Mice

57 Pages Posted: 7 Apr 2018 Publication Status: Review Complete

See all articles by Tomokazu Hata

Tomokazu Hata

Kyushu University - Department of Psychosomatic Medicine

Noriyuki Miyata

Kyushu University - Department of Psychosomatic Medicine

Shu Takakura

Kyushu University - Department of Psychosomatic Medicine

Kazufumi Yoshihara

Kyushu University - Department of Psychosomatic Medicine

Yasunari Asano

Kyushu University - Department of Psychosomatic Medicine

Tae Kimura-Todani

Kyushu University - Department of Psychosomatic Medicine

Makoto Yamashita

Kyushu University - Department of Psychosomatic Medicine

Xue-Ting Zhang

Kyushu University - Department of Psychosomatic Medicine

Natsuru Watanabe

Tokai University - Department of Infectious Diseases; Tokai University - Department of Psychiatry

Katsunaka Mikami

Tokai University - Department of Psychiatry

Yuji Aiba

Tokai University - Department of Infectious Diseases; Tokai University - Department of Psychiatry

Yasuhiro Koga

Tokai University - Department of Infectious Diseases

Nobuyuki Sudo

Kyushu University - Department of Psychosomatic Medicine

More...

Abstract

It was previously established that anorexia nervosa (AN) results in gut dysbiosis; however, whether this can actually contribute to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. Therefore, germ-free mice were reconstituted with the microbiota of anorexia nervosa restricting-type patients (gAN mice) and healthy control individuals (gHC mice), and the effects of gut microbes on weight gain and behavioral characteristics were examined. Fecal microbial profiles in recipient gnotobiotic mice clustered with those of the human donors. Despite no difference in food intake between the two groups, body weight gain was impaired in gAN mice. In addition, anxiety-related behavior was increased only in gAN mice compared to that in corresponding gHC animals, and this phenotype was reversed through the administration of Bacteroides vulgatus. Collectively, these results indicate that AN-specific dysbiosis might contribute to both poor weight gain and mental disorders identified in AN patients.

Suggested Citation

Hata, Tomokazu and Miyata, Noriyuki and Takakura, Shu and Yoshihara, Kazufumi and Asano, Yasunari and Kimura-Todani, Tae and Yamashita, Makoto and Zhang, Xue-Ting and Watanabe, Natsuru and Mikami, Katsunaka and Aiba, Yuji and Koga, Yasuhiro and Sudo, Nobuyuki, The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Mice (2018). Available at SSRN: https://ssrn.com/abstract=3155625 or http://dx.doi.org/10.2139/ssrn.3155625
This version of the paper has not been formally peer reviewed.

Tomokazu Hata

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Noriyuki Miyata

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Shu Takakura

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Kazufumi Yoshihara

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Yasunari Asano

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Tae Kimura-Todani

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Makoto Yamashita

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Xue-Ting Zhang

Kyushu University - Department of Psychosomatic Medicine

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

Natsuru Watanabe

Tokai University - Department of Infectious Diseases

Shonan Campus: 4-1-1 Kitakaname
Hiratsuka-shi
Kanagawa, 259-1292
Japan

Tokai University - Department of Psychiatry

Shonan Campus: 4-1-1 Kitakaname
Hiratsuka-shi
Kanagawa, 259-1292
United States

Katsunaka Mikami

Tokai University - Department of Psychiatry

Shonan Campus: 4-1-1 Kitakaname
Hiratsuka-shi
Kanagawa, 259-1292
United States

Yuji Aiba

Tokai University - Department of Infectious Diseases

Shonan Campus: 4-1-1 Kitakaname
Hiratsuka-shi
Kanagawa, 259-1292
Japan

Tokai University - Department of Psychiatry

Shonan Campus: 4-1-1 Kitakaname
Hiratsuka-shi
Kanagawa, 259-1292
United States

Yasuhiro Koga

Tokai University - Department of Infectious Diseases

Shonan Campus: 4-1-1 Kitakaname
Hiratsuka-shi
Kanagawa, 259-1292
Japan

Nobuyuki Sudo (Contact Author)

Kyushu University - Department of Psychosomatic Medicine ( email )

3-1-1, Maidashi
Higashi-ku
Fukuoka City, 812-8582
Japan

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