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Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons

32 Pages Posted: 5 Apr 2018 Publication Status: Published

See all articles by Sam A. Booker

Sam A. Booker

Charité - Universitätsmedizin Berlin - Institute of Integrative Neuroanatomy

Desiree Loreth

University of Freiburg - Institute of Physiology

Annabelle L. Gee

University of Glasgow - Institute for Neuroscience

Masahiko Watanabe

Hokkaido University - Department of Anatomy

Peter C. Kind

University of Edinburgh - Centre for Integrative Physiology

David J.A. Wyllie

University of Edinburgh - Centre for Integrative Physiology

Ákos Kulik

University of Freiburg - Institute of Physiology

Imre Vida

Charité - Universitätsmedizin Berlin - Institute of Integrative Neuroanatomy

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Abstract

Inhibition provided by a diverse set of local GABAergic interneurons (INs) activates both ionotropic GABAA and metabotropic GABAB receptors. Despite the fact that GABAB receptors represent a major source of inhibition onto INs, little is known of their function in distinct IN subtypes. Here we show that while the archetypal dendritic-inhibitory somatostatin-expressing INs (SOM-INs ) possess high levels of GABAB receptors and G-protein coupled inward-rectifying K (Kir3) channels on their somato-dendritic surface, they fail to produce significant postsynaptic inhibitory currents. Instead, GABAB receptors selectively inhibit dendritic CaV1.2 (L- type) Ca2 channels on dendrites of SOM-INs, leading to attenuation of calcium influx and loss of long-term potentiation at excitatory input synapses onto these INs. These data provide a novel mechanism by which GABABRs can contribute to disinhibition and control of efficacy of CA3 and entorhinal cortex synaptic inputs in hippocampal networks.

Suggested Citation

Booker, Sam A. and Loreth, Desiree and Gee, Annabelle L. and Watanabe, Masahiko and Kind, Peter C. and Wyllie, David J.A. and Kulik, Ákos and Vida, Imre, Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons (2018). Available at SSRN: https://ssrn.com/abstract=3155713 or http://dx.doi.org/10.2139/ssrn.3155713
This version of the paper has not been formally peer reviewed.

Sam A. Booker

Charité - Universitätsmedizin Berlin - Institute of Integrative Neuroanatomy

Campus Charité Mitte
Berlin, 10117
United States

Desiree Loreth

University of Freiburg - Institute of Physiology

Hermann-Herder-Str. 7
Freiburg, 79104
Germany

Annabelle L. Gee

University of Glasgow - Institute for Neuroscience

Glasgow, Scotland G12 8LE
United Kingdom

Masahiko Watanabe

Hokkaido University - Department of Anatomy

Sapporo, Hokkaido 060-0809
Japan

Peter C. Kind

University of Edinburgh - Centre for Integrative Physiology

Edinburgh, Scotland EH8 9JY
United Kingdom

David J.A. Wyllie

University of Edinburgh - Centre for Integrative Physiology

Edinburgh, Scotland EH8 9JY
United Kingdom

Ákos Kulik

University of Freiburg - Institute of Physiology

Hermann-Herder-Str. 7
Freiburg, 79104
Germany

Imre Vida (Contact Author)

Charité - Universitätsmedizin Berlin - Institute of Integrative Neuroanatomy ( email )

Campus Charité Mitte
Berlin, 10117
United States

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