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Proximodistal Organization of the CA2 Hippocampal Area

45 Pages Posted: 8 Jun 2018 Publication Status: Review Complete

See all articles by I. Fernandez-Lamo

I. Fernandez-Lamo

University of Malaga - Instituto Cajal

D. Gomez-Dominguez

University of Malaga - Instituto Cajal

A. Sanchez-Aguilera

University of Malaga - Instituto Cajal

E. Cid

University of Malaga - Instituto Cajal

M. Valero

University of Malaga - Instituto Cajal

Liset Menendez de la Prida

University of Malaga - Instituto Cajal

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Abstract

The proximodistal axis is considered a major organizational principle of the hippocampus. Interfacing between the hippocampus and other brain systems, the CA2 region apparently breaks this rule. Apart from its specific role in social memory, CA2 has been involved in temporal and contextual memory but mechanisms remain elusive. Here, we used intracellular and extracellular recordings followed by neurochemical identification of single-cells to evaluate CA2 and surrounding areas in the rat. We found marked proximodistal trends of synaptic activity, as well as in subthreshold membrane potentials and phase-locked firing coupled to theta and gamma oscillations. Opposite proximodistal correlations between membrane potential fluctuations and theta sinks and sources at different layers revealed influences from up to three different generators. CA2 memory engrams established after a social memory task reflected these trends. We suggest that the structure and function of CA2 is segregated along the proximodistal hippocampal axis.

Suggested Citation

Fernandez-Lamo, I. and Gomez-Dominguez, D. and Sanchez-Aguilera, A. and Cid, E. and Valero, M. and Menendez de la Prida, Liset, Proximodistal Organization of the CA2 Hippocampal Area (2018). Available at SSRN: https://ssrn.com/abstract=3192037 or http://dx.doi.org/10.2139/ssrn.3192037
This version of the paper has not been formally peer reviewed.

I. Fernandez-Lamo

University of Malaga - Instituto Cajal

Ave Doctor Arce 37
Madrid, E-28002
Spain

D. Gomez-Dominguez

University of Malaga - Instituto Cajal

Ave Doctor Arce 37
Madrid, E-28002
Spain

A. Sanchez-Aguilera

University of Malaga - Instituto Cajal

Ave Doctor Arce 37
Madrid, E-28002
Spain

E. Cid

University of Malaga - Instituto Cajal

Ave Doctor Arce 37
Madrid, E-28002
Spain

M. Valero

University of Malaga - Instituto Cajal

Ave Doctor Arce 37
Madrid, E-28002
Spain

Liset Menendez de la Prida (Contact Author)

University of Malaga - Instituto Cajal ( email )

Ave Doctor Arce 37
Madrid, E-28002
Spain