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Normal Triglyceride is Associated with Insulin Resistance in the Absence of Risk Factors

30 Pages Posted: 30 Jun 2018

See all articles by Yan Yao

Yan Yao

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Chunli Bi

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Lijuan Wang

Jilin University (JLU) - Department of Neurology

Chong Sun

Jilin University (JLU) - Key Laboratory of Organ Regeneration and Transplantation; Jilin University (JLU) - Department of Epidemiology and Biostatistics

Mengzi Sun

Jilin University (JLU) - Key Laboratory of Organ Regeneration and Transplantation; Jilin University (JLU) - Department of Epidemiology and Biostatistics

Zhiqing Xue

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Li Shen

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Pan Pan

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Pingping Zheng

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Yaogai Lv

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Jiagen Li

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Anning Zhang

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Bo Li

Jilin University (JLU) - Department of Epidemiology and Biostatistics

Xinyao Zhang

Jilin University (JLU) - Department of Social Medicine and Health Management

Lina Jin

Jilin University (JLU) - Key Laboratory of Organ Regeneration and Transplantation; Jilin University (JLU) - Department of Epidemiology and Biostatistics

More...

Abstract

BACKGROUND: Traditionally, absence of insulin resistance risk factors (IRRFs) is considered low risk for insulin resistance (IR). However, even individuals without IRRFs still have IR. This study aimed to explore the predictors of IR among the population who are non-smokers, non-diabetic and non-obese with normal blood pressure and lipids.

METHODS: The data was derived from the 2007-2014 National Health and Nutrition Survey (NHANES). Participants without regular insulin resistance risk factors (IRRF-Free, n =2 317) and a subgroup without optimal insulin resistance risk factors (IRRF-Optimal, n =1 325) were involved to explore predictors of IR, which was indexed by homeostatic model assessment (HOMA). The logistic regression model and the areas under receiver operating characteristic curve (AUROC) were used to evaluate IRRFs and the predictive capacity, and Jordan index was performed to determine the optimal cut-off value of triglyceride (TG) to predict IR in IRRF-Free and IRRF-Optimal.

FINDINGS: The prevalences of IR were 6.9% and 5.8% in IRRF-Free and IRRFOptimal respectively. TG and waist circumference (WC) were independently associated with the prevalence of IR (P<0·05) in both the IRRF-Free and IRRF-Optimal, where TG was positively associated with IR. The AUROC of TG was 0·7013 (95% CI 0·7011-0·7016) and 0·7180 (95% CI 0·7176-0·7183) in IRRF-Free and IRRF-Optimal respectively, and the optimal cut-off value of TG to predict IR for the two groups were both 87·5 mg/dl.

INTERPRETATION: TG, even at levels currently considered normal, was independently associated with IR in the absence of IRRFs. TG can be used as an important indicator to predict the prevalence of IR.

FUNDING: The Natural Science Foundation of Science and Technology Department of Jilin Province, China; the Outstanding Youth Foundation of Science and Technology Department of Jilin Province, China; the National Natural Science Foundation of China; the National Key Research and Development Program of China.

DECLARATIONS OF INTERESTS: No other potential conflicts of interest relevant to this article were reported.

All subjects provided written informed consent, and the study was approved by the NCHS Research Ethics Review Board (ERB).

Keywords: Insulin resistance; Triglyceride; Risk factors; Receiver operating characteristic curve

Suggested Citation

Yao, Yan and Bi, Chunli and Wang, Lijuan and Sun, Chong and Sun, Mengzi and Xue, Zhiqing and Shen, Li and Pan, Pan and Zheng, Pingping and Lv, Yaogai and Li, Jiagen and Zhang, Anning and Li, Bo and Zhang, Xinyao and Jin, Lina, Normal Triglyceride is Associated with Insulin Resistance in the Absence of Risk Factors (June 29, 2018). Available at SSRN: https://ssrn.com/abstract=3205594 or http://dx.doi.org/10.2139/ssrn.3205594

Yan Yao

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Chunli Bi

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Lijuan Wang

Jilin University (JLU) - Department of Neurology ( email )

Changchun, Jilin 130021
China

Chong Sun

Jilin University (JLU) - Key Laboratory of Organ Regeneration and Transplantation ( email )

China

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Mengzi Sun

Jilin University (JLU) - Key Laboratory of Organ Regeneration and Transplantation ( email )

China

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Zhiqing Xue

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Li Shen

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Pan Pan

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Pingping Zheng

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Yaogai Lv

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Jiagen Li

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Anning Zhang

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Bo Li

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China

Xinyao Zhang

Jilin University (JLU) - Department of Social Medicine and Health Management ( email )

Changchun, Jilin 130021
China

Lina Jin (Contact Author)

Jilin University (JLU) - Key Laboratory of Organ Regeneration and Transplantation ( email )

China

Jilin University (JLU) - Department of Epidemiology and Biostatistics ( email )

1163 Xinmin Street
Changchun, Jilin 130021
China