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Associations between Typical Environmental Factors and the Risk of Fetal Neural Tube Defects in North China

41 Pages Posted: 9 Aug 2018

See all articles by Bin Wang

Bin Wang

Peking University - Department of Epidemiology and Biostatistics

Lailai Yan

Peking University, School of Public Health, Department of Laboratorial Science and Technology

Zhenjiang Li

Peking University - Department of Epidemiology and Biostatistics

Yibing Zhu

Peking University - Department of Epidemiology and Biostatistics

Mingliang Fang

Nanyang Technological University (NTU) - School of Civil and Environmental Engineering

Da Chen

Jinan University - School of Environment

Qian Liu

Chinese Academy of Sciences (CAS) - State Key Laboratory of Environmental Chemistry and Ecotoxicology

Xiaoxia Lu

Peking University - College of Urban and Environmental Sciences

Nan Li

Peking University - Department of Epidemiology and Biostatistics

Yingying Liu

Peking University - Department of Epidemiology and Biostatistics

Xiaoqian Jia

Peking University - Department of Epidemiology and Biostatistics

Yongxiu Hao

Peking University - Department of Epidemiology and Biostatistics

Yiming Pang

Peking University - Department of Epidemiology and Biostatistics

Huina Yan

Peking University - Department of Epidemiology and Biostatistics

Tanxin Liu

Peking University - Department of Epidemiology and Biostatistics

Zixi Cheng

Peking University - Department of Epidemiology and Biostatistics

Jingxu Zhang

Peking University - Department of Child, Adolescent and Women’s Health

Rongwei Ye

Peking University - Department of Epidemiology and Biostatistics

Zhiwen Li

Peking University - Institute of Reproductive and Child Health; Peking University - Department of Epidemiology and Biostatistics

Aiguo Ren

Peking University - Department of Epidemiology and Biostatistics

More...

Abstract

Background: The relationship between the levels of various environmental chemicals and the high prevalence of neural tube defects (NTDs) in north China remains unclear. This study aimed to classify the associations of maternal exposure to polycyclic aromatic hydrocarbons (PAHs), passive smoking, and widely concerned trace metal elements with NTD risk.
Methods: Our case-control study recruited a total of 828 subjects: 285 women who delivered a fetus with NTDs (cases) and 543 women a healthy newborn without NTDs (controls). We measured the concentrations of PAHs, nicotine/cotinine, and various trace metal elements in two hair sections grown near the early pregnancy.
Findings: Overall, no significant associations were found between the risk of any NTD subtypes and the hair levels of PAHs, nicotine/cotinine, and some metals (i.e., Cd, Sb, Pb, Cr, Mn, Fe, Ni, Co, and Cu). According to the cross-validation results for the two hair sections, hair concentrations of Mo and Sn were inversely associated with anencephaly risk, and the hair concentration of Zn was inversely associated with the risk of spina bifida. Interpretation: We concluded that maternal exposure to either PAHs or passive smoking was not a significant risk factor for NTDs, whereas the maternal less intake of certain trace metal elements may contribute to the high NTD prevalence in north China. It suggested that much effort should be spent to improve the dietary quality of various essential trace metal elements to reduce NTD risk for population living in North China.
Funding: This research was supported by grants from the National Key Research and Development Program, P.R. China (Grant No. 2016YFC1000501) and the National Natural Science Foundation of China (No. 41771527 and 81373014).
Conflict of Interest: The authors declare they have no actual or potential competing financial interests.
Ethics Approval Statement: The study protocol was approved by the Institutional Review Board of Peking University (PU-IRB) and the signed consent was obtained from all subjects.

Keywords: Neural tube defects, polycyclic aromatic hydrocarbons, passive smoking, trace metals, hair

Suggested Citation

Wang, Bin and Yan, Lailai and Li, Zhenjiang and Zhu, Yibing and Fang, Mingliang and Chen, Da and Liu, Qian and Lu, Xiaoxia and Li, Nan and Liu, Yingying and Jia, Xiaoqian and Hao, Yongxiu and Pang, Yiming and Yan, Huina and Liu, Tanxin and Cheng, Zixi and Zhang, Jingxu and Ye, Rongwei and Li, Zhiwen and Ren, Aiguo, Associations between Typical Environmental Factors and the Risk of Fetal Neural Tube Defects in North China (July 20, 2018). Available at SSRN: https://ssrn.com/abstract=3218736 or http://dx.doi.org/10.2139/ssrn.3218736

Bin Wang

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Lailai Yan

Peking University, School of Public Health, Department of Laboratorial Science and Technology

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Zhenjiang Li

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Yibing Zhu

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Mingliang Fang

Nanyang Technological University (NTU) - School of Civil and Environmental Engineering

S3 B2-A28 Nanyang Avenue
Singapore, 639798
Singapore

Da Chen

Jinan University - School of Environment

Huang Pu Da Dao Xi 601, Tian He District
Guangzhou, Guangdong 510632
China

Qian Liu

Chinese Academy of Sciences (CAS) - State Key Laboratory of Environmental Chemistry and Ecotoxicology

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Xiaoxia Lu

Peking University - College of Urban and Environmental Sciences

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Nan Li

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Yingying Liu

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Xiaoqian Jia

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Yongxiu Hao

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Yiming Pang

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Huina Yan

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Tanxin Liu

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Zixi Cheng

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Jingxu Zhang

Peking University - Department of Child, Adolescent and Women’s Health

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Rongwei Ye (Contact Author)

Peking University - Department of Epidemiology and Biostatistics ( email )

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Zhiwen Li

Peking University - Institute of Reproductive and Child Health ( email )

Peking University - Department of Epidemiology and Biostatistics ( email )

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Aiguo Ren

Peking University - Department of Epidemiology and Biostatistics

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

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