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Cholinergic Interneurons as a Novel Target of CRF in the Striatum that is Spared by Repeated Stress

53 Pages Posted: 9 Nov 2018 Publication Status: Under Review

See all articles by Julia C. Lemos

Julia C. Lemos

NIH - National Institute on Alcohol Abuse and Alcoholism

Jung Hoon Shin

NIH - National Institute on Alcohol Abuse and Alcoholism

Anna E. Ingebretson

University of Minnesota - Minneapolis - Department of Neuroscience

Lauren K. Dobbs

NIH - National Institute on Alcohol Abuse and Alcoholism

Veronica Alvarez

National Institutes of Health (NIH) - Laboratory on Neurobiology of Compulsive Behaviors

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Abstract

Acute stressors can stimulate appetitive and exploratory behaviors, not just produce negative affect that impair performance. Corticotropin releasing factor (CRF), which is released in the brain in response to stress, acts on different targets and circuits to mediate both the negative and positive effects of stress. In the nucleus accumbens, CRF facilitates appetitive behavior through mechanisms not fully understood. Here we report that cholinergic interneurons (CINs) are a novel target for CRF actions in the striatum. CRF enhances the spontaneous firing via activation of CRF-type 1 receptors expressed on CINs. This causes the activation muscarinic acetylcholine receptors type 5, which mediate CRF potentiation of dopamine transmission in the striatum. Repeated stress selectively dampens some CRF functions but spare effect on CINs and changes CRF-R1 expression in a cell-specific manner. These data highlight the existence of diverse CRF targets within the striatum, which vary in their resilience to stress.

Suggested Citation

Lemos, Julia C. and Shin, Jung Hoon and Ingebretson, Anna E. and Dobbs, Lauren K. and Alvarez, Veronica, Cholinergic Interneurons as a Novel Target of CRF in the Striatum that is Spared by Repeated Stress (November 7, 2018). Available at SSRN: https://ssrn.com/abstract=3280248 or http://dx.doi.org/10.2139/ssrn.3280248
This version of the paper has not been formally peer reviewed.

Julia C. Lemos

NIH - National Institute on Alcohol Abuse and Alcoholism

9000 Rockville Pike
Bethesda, MD 20892
United States

Jung Hoon Shin

NIH - National Institute on Alcohol Abuse and Alcoholism

9000 Rockville Pike
Bethesda, MD 20892
United States

Anna E. Ingebretson

University of Minnesota - Minneapolis - Department of Neuroscience

110 Wulling Hall, 86 Pleasant St, S.E.
308 Harvard Street SE
Minneapolis, MN 55455
United States

Lauren K. Dobbs

NIH - National Institute on Alcohol Abuse and Alcoholism

9000 Rockville Pike
Bethesda, MD 20892
United States

Veronica Alvarez (Contact Author)

National Institutes of Health (NIH) - Laboratory on Neurobiology of Compulsive Behaviors ( email )

United States