University of Texas at Houston, McGovern Medical School, Graduate School of Biological Sciences, Brown Foundation Institute of Molecular Medicine and Program in Neuroscience
The role of neuropeptides agouti-related peptide (AgRP) and neuropeptide Y (NPY) in feeding behavior regulation have been extensively studied in rodents. However, the biological functions of these peptides in primates are not fully addressed. Here we shown that, through Lenti-virus mediated selective expression of human NPY (hNPY) or human AgRP (hAgRP) in the paraventricular nucleus (PVN), the bodyweight was significantly increased in young Rhesus Macaques. Whereas, the blood level of glucose and insulin, as well as metabolic parameters, including blood level of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-esterified free fatty acids (NEFA) and leptin remain unchanged after virus injection. Although further investigations of long-term effects are needed, these results have recapitulated some parts of previous reports in rodents, and suggest that these non-germlines geneticlly modified monkeys may provide new models for studying feeding behaviors and related disease, such as obesity and diabetes.
Zhou, Tao and Tang, Ke and Wang, Zhengwu and Ke, Zun-Fu and Huang, Fan and Tan, Ruizhi and Luo, Xu and Ling, Xujiao and Zhang, Xuliang and Wang, Li and Zhao, Xudong and Li, Hongli and Fan, Shengjie and Hong, Shubin and Peng, Sui and Tong, Qingchun and Huang, Xingxu and Fan, Junming and Xiao, Haipeng and Xiao, Haipeng and Huang, Cheng, Overexpression of Human NPY or AgRP in the Paraventricular Nucleus Increase Bodyweight in Young Rhesus Macaques (November 13, 2018). Available at SSRN: https://ssrn.com/abstract=3283709 or http://dx.doi.org/10.2139/ssrn.3283709
This version of the paper has not been formally peer reviewed.
University of Texas at Houston, McGovern Medical School, Graduate School of Biological Sciences, Brown Foundation Institute of Molecular Medicine and Program in Neuroscience ( email )
Subscribe to this free journal for more curated articles on this topic
FOLLOWERS
20
PAPERS
9,122
Feedback
Feedback to SSRN
If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday.