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Antibiotic Bacillomycin D Regulates Biofilm Development Through the FeuABC-Dependent Iron Acquisition Pathway

59 Pages Posted: 12 Dec 2018 Publication Status: Published

See all articles by Zhihui Xu

Zhihui Xu

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Ines Mandic-Mulec

University of Ljubljana - Department of Food Science and Technology

Huihui Zhang

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Yan Liu

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Xinli Sun

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Weibing Xun

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nan Zhang

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Qirong Shen

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Ruifu Zhang

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

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Abstract

Bacillus spp. produce a wide range of secondary metabolites, including antibiotics, which have been well studied for their antibacterial properties but less so as signaling molecules. Previous results indicated that lipopeptide bacillomycin D is a signal that promotes biofilm development of Bacillus velezensis SQR9. However, a mechanism behind this signaling is still unknown. Here we showed that bacillomycin D promotes biofilm development by promoting the acquisition of iron. It does so through two routes. First, it promotes the transcription of specific iron acquisition genes. Second, it increases the binding of the Ferri-siderophore bacillibactin to the iron transporter. These actions increase intracellular iron concentration, activate the KinB-Spo0A-SinI dependent synthesis of biofilm matrix components. We demonstrate that this strategy is beneficial for biofilm development and during competition with the Pseudomonas fluorescens PF-5. Our results unravels a antibiotic dependent signaling mechanism that links iron acquisition to biofilm development and ecological competition.

Keywords: Bacillomycin D, FeuABC, Biofilm, Signaling peptide, Intraspecific competition

Suggested Citation

Xu, Zhihui and Mandic-Mulec, Ines and Zhang, Huihui and Liu, Yan and Sun, Xinli and Xun, Weibing and Zhang, Nan and Shen, Qirong and Zhang, Ruifu, Antibiotic Bacillomycin D Regulates Biofilm Development Through the FeuABC-Dependent Iron Acquisition Pathway (December 12, 2018). Available at SSRN: https://ssrn.com/abstract=3299437 or http://dx.doi.org/10.2139/ssrn.3299437
This version of the paper has not been formally peer reviewed.

Zhihui Xu (Contact Author)

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization ( email )

Nanjing, 210095
China

Ines Mandic-Mulec

University of Ljubljana - Department of Food Science and Technology

Dunajska 104
Ljubljana, 1000
Slovenia

Huihui Zhang

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nanjing, 210095
China

Yan Liu

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nanjing, 210095
China

Xinli Sun

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nanjing, 210095
China

Weibing Xun

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nanjing, 210095
China

Nan Zhang

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nanjing, 210095
China

Qirong Shen

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization

Nanjing, 210095
China

Ruifu Zhang

Nanjing Agricultural University (NAU) - Jiangsu Provincial Key Lab for Solid Organic Waste Utilization ( email )

Nanjing, 210095
China

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