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Interaction Between FKBP5 Polymorphisms and Childhood Trauma on Depressive Symptoms: The Moderating Role of Resilience

20 Pages Posted: 4 Jan 2019

See all articles by Chun Kang

Chun Kang

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

JunXin Shi

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Minli Zhang

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Huisi Ding

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Jishan Wei

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Yusha Gong

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Kaiqiao Wang

East Lake New Technology Development Zone

Yizhen Yu

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Sichao Wang

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

Juan Han

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

More...

Abstract

Background: Previous gene-environment studies on depression have examined the interaction between FKBP5 gene and childhood trauma, but the results are inconsistent and few studies have focused on Asian adolescents. Psychological resilience may explain for the inconsistency. We examined the interaction between FKBP5 gene and childhood trauma on depressive symptoms in Chinese adolescents, and firstly explored the role of resilience in the relationship.  

Methods: This study comprised 942 participants (448 males, 47.6%) randomly recruited from four senior schools in Wuhan, Hubei of China. Depressive symptoms, childhood trauma, and resilience data were collected. Three potentially functional FKBP5 SNPs were selected for genotyping.  

Findings: Participants carrying minor alleles of FKBP5 polymorphisms (rs3800373, rs1360780, and rs4713916) and a haplotype derived from these SNPs interacted with childhood physical abuse predicted higher CES-D scores after considering the effect of resilience (Padj for interactions <0.05). However, the interaction effects only displayed great significance in the low resilience group (Padj <0.01), but not in moderate or high resilience groups (Padj> 0.05).  

Interpretation: FKBP5 variants in combination with childhood physical abuse predict more pronounced depressive symptoms among Chinese adolescents, while resilience plays a moderating role in the associations. Our findings suggest measures combining childhood trauma prevention with promoting resilience might yield better to decrease depression problems in adolescents.  

Funding Statement: This study was supported by a grant from National Natural Science Foundation of China (grant number 81472995).  

Declaration of Interests: The authors declare no conflict of interests.

Ethics Approval Statement: This study was approved by the Human Research Ethics Committee, Huazhong University of science and technology ([2014] IEC (S088)).

Keywords: Depression, Childhood-trauma, FKBP5, Resilience, Interaction

Suggested Citation

Kang, Chun and Shi, JunXin and Zhang, Minli and Ding, Huisi and Wei, Jishan and Gong, Yusha and Wang, Kaiqiao and Yu, Yizhen and Wang, Sichao and Han, Juan, Interaction Between FKBP5 Polymorphisms and Childhood Trauma on Depressive Symptoms: The Moderating Role of Resilience (December 26, 2018). Available at SSRN: https://ssrn.com/abstract=3307681 or http://dx.doi.org/10.2139/ssrn.3307681

Chun Kang

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

JunXin Shi

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Minli Zhang

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Huisi Ding

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Jishan Wei

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Yusha Gong

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Kaiqiao Wang

East Lake New Technology Development Zone

Wuhan
China

Yizhen Yu

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Sichao Wang

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

Juan Han (Contact Author)

Huazhong University of Science and Technology - Department of Maternal, Child and Adolescent Health ( email )

No.13 Hankong Road 13
Wuhan City, Hubei Province 430030
China

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