The Blood Compatibility Challenge. Part 4: Surface Modification for Hemocompatible Materials: Passive and Active Approaches to Guide Blood-Material Interactions
Universidade do Porto - Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto - Instituto de Engenharia Biomédica (INEB); Universidade do Porto - Institute of Biomedical Sciences Abel Salazar (ICBAS)
Universitätsmedizin Rostock - Institut für Biomedizinische Technik; Universitätsmedizin Rostock - Institute for ImplantTechnology and Biomaterials (IIB)
Harvard University - Beth Israel Deaconess Medical Center; Harvard University - Wyss Institute for Biologically Inspired Engineering; Massachusetts Institute of Technology (MIT) - Harvard-MIT Division of Health Sciences and Technology
Universidade do Porto - Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto - Instituto de Engenharia Biomédica (INEB); Universidade do Porto - Institute of Biomedical Sciences Abel Salazar (ICBAS)
Leibniz-Institut für Polymerforschung Dresden, Max Bergmann Center of Biomaterials, Institute Biofunctional Polymer Materials
Abstract
Biomedical devices in the blood flow disturb the fine-tuned balance of pro- and anti-coagulant factors in blood and vessel wall. Numerous technologies have been suggested to reduce coagulant and inflammatory responses of the body towards the device material, ranging from camouflage effects to permanent activity and further to a responsive interaction with the host systems. However, not all types of modification are suitable for all types of medical products.This review has a focus on application-oriented considerations of hemocompatible surface fittings. Thus, passive versus bioactive modifications are discussed along with the control of protein adsorption, stability of the immobilization, and the type of bioactive substance,biological or synthetic. Further considerations are related to the target system, whether enzymes or cells should be addressed in arterial or venous system, or whether the blood vessel wall is addressed. Recent developments like feedback controlled or self-renewing systems for drug release or addressing cellular regulation pathways of blood platelets and endothelial cells are paradigms for a generation of blood contacting devices, which are hemocompatible by cooperation with the host system.
Maitz, Manfred F. and Martins, M. Cristina L. and Grabow, Niels and Matschegewski, Claudia and Huang, Nan and Chaikof, Elliot L. and Barbosa, Mário A. and Werner, Carsten and Sperling, Claudia, The Blood Compatibility Challenge. Part 4: Surface Modification for Hemocompatible Materials: Passive and Active Approaches to Guide Blood-Material Interactions (May 14, 2019). Available at SSRN: https://ssrn.com/abstract=3387675 or http://dx.doi.org/10.2139/ssrn.3387675
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