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Survival Analysis of Immune-Related lncRNA in Low-Grade Glioma

15 Pages Posted: 3 Jun 2019

See all articles by Xiaozhi Li

Xiaozhi Li

China Medical University - Department of Stomatology

Yutong Meng

China Medical University - Department of Stomatology

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Abstract

Introduction: Low-grade glioma is grade I-II glioma. Immunotherapy is a promising way of tumor killing. Research on immune molecular mechanisms in low-grade gliomas and discovery of new immune checkpoints for low-grade gliomas are of great importance.

Materials and Methods: Gene sequencing data and clinical data of low-grade glioma were downloaded from TCGA database. Prognosis related lncRNAs were identified by COX regression and their possible functions were found by gene enrichment set analysis.

Results: A total of 529 low-grade glioma samples and 5 non-tumor brain tissue samples are obtained from the TCGA database. 247 immune-associated lncRNAs are screened. Cox regression showed that 23 immune-related lncRNAs are associated with low-grade glioma prognosis, and 7 lncRNAs are independent risk factors. Gene set enrichment analysis suggests that these molecules are enriched in extracellular regions, sequence-specific DNA binding, neuropeptide signaling pathway, positive regulation of B cell activation, etc.

Conclusion: The identification of immune-related lncRNA may provide new targets for the research of the molecular mechanisms and treatment of low-grade glioma.

Funding Statement: The authors state: "Not applicable."

Declaration of Interests: The authors state: "Not applicable."

Ethics Approval Statement: The authors declare: "As all of these data were retrieved from TCGA database which are open to the public under guidelines, it is confirmed that all informed consent was achieved."

Keywords: low-grade glioma, lncRNA, immune, prognosis

Suggested Citation

Li, Xiaozhi and Meng, Yutong, Survival Analysis of Immune-Related lncRNA in Low-Grade Glioma (May 30, 2019). Available at SSRN: https://ssrn.com/abstract=3397185 or http://dx.doi.org/10.2139/ssrn.3397185

Xiaozhi Li

China Medical University - Department of Stomatology

No. 91 Hsueh-Shih Road
Taichung, 40402
Taiwan

Yutong Meng (Contact Author)

China Medical University - Department of Stomatology ( email )

No. 91 Hsueh-Shih Road
Taichung, 40402
Taiwan

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