lancet-header

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.

Temporal Changes in Cardiorespiratory Fitness and Risk of Dementia Incidence and Mortality - Results from the HUNT Study

35 Pages Posted: 29 Jun 2019

See all articles by Atefe R. Tari

Atefe R. Tari

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Javaid Nauman

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Nina Zisko

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Håvard K. Skjellegrind

Norwegian University of Science and Technology (NTNU) - Faculty of Medicine and Health Sciences

Ingunn Bosnes

Høgskolen i Nord-Trøndelag

Sverre Bergh

Vestfold Hospital Trust

Dorthe Stensvold

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Geir Selbæk

Vestfold Hospital Trust

Ulrik Wisloff

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging; University of Queensland - School of Human Movement & Nutrition Sciences

More...

Abstract

Background: Cardiorespiratory fitness (CRF) is associated with risk of dementia, but it is not known whether temporal changes in CRF influence the risk of dementia incidence- and mortality.

Methods: Data from the prospective Nord-Trøndelag Health Study (HUNT, n=30,695) was linked to dementia incidence and cause of death registries. CRF was assessed on two occasions 10 years apart, and the second assessment was used as baseline for follow-up. Using Cox proportional hazard analyses, adjusted hazard ratios (AHR) were estimated for dementia incidence- and mortality related to temporal changes in CRF.

Findings: During a median follow-up of 19.6 years for mortality, and 7.6 years for incidence, there were 814 dementia related deaths, and 320 incident dementia cases. Compared with unfit participants at both assessments, participants who sustained high CRF had 40% reduced risk of incident dementia (AHR: 0.60; 95% CI: 0.36-0.99), and 44% reduced risk of dementia mortality (AHR: 0.56; 95% CI: 0.43-0.75). Participants who increased their CRF over time, reduced the risk of incident dementia and dementia mortality with 48% (AHR: 0.52; 95% CI: 0.30-0.90), and 28% (AHR: 0.72; 95% CI: 0.52-0.99), respectively. Each MET increase in CRF was associated with 16% and 10% relative risk reduction of incident dementia and dementia mortality, respectively. Participants who increased their CRF over time gained 2.2 (95% CI: 1.0-3.5) dementia free years, and 2.7 (95% CI: 0.4-5.8) years of life.

Interpretation: Maintaining or improving CRF over time may be a target to reduce risk of dementia- incidence and mortality, delay onset and increase longevity after diagnosis. Our data highlight the importance of assessing CRF in health risk assessment for people at risk of dementia.

Funding Statement: The K.G. Jebsen Foundation, the Norwegian Research Council, the Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and Technology.

Declaration of Interests: All authors declare no competing interests.

Ethics Approval Statement: The study was approved by the Data Inspectorate and the Regional Committee on Medical and Health Research Ethics of Norway (2015/2015/REK midt).

Keywords: Cardiorespiratory fitness, PeakVO2, Alzheimer disease, Dementia

Suggested Citation

Tari, Atefe R. and Nauman, Javaid and Zisko, Nina and Skjellegrind, Håvard K. and Bosnes, Ingunn and Bergh, Sverre and Stensvold, Dorthe and Selbæk, Geir and Wisloff, Ulrik, Temporal Changes in Cardiorespiratory Fitness and Risk of Dementia Incidence and Mortality - Results from the HUNT Study (June 27, 2019). Available at SSRN: https://ssrn.com/abstract=3410909 or http://dx.doi.org/10.2139/ssrn.3410909

Atefe R. Tari

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Trondheim
Norway

Javaid Nauman

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Trondheim
Norway

Nina Zisko

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Trondheim
Norway

Håvard K. Skjellegrind

Norwegian University of Science and Technology (NTNU) - Faculty of Medicine and Health Sciences

Trondheim NO-7491
Norway

Ingunn Bosnes

Høgskolen i Nord-Trøndelag

Steinkjer
Norway

Sverre Bergh

Vestfold Hospital Trust

Tönsberg
Norway

Dorthe Stensvold

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging

Trondheim
Norway

Geir Selbæk

Vestfold Hospital Trust

Tönsberg
Norway

Ulrik Wisloff (Contact Author)

Norwegian University of Science and Technology (NTNU) - Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging ( email )

Trondheim
Norway

University of Queensland - School of Human Movement & Nutrition Sciences ( email )

St. Lucia
Australia

Click here to go to TheLancet.com

Paper statistics

Downloads
75
Abstract Views
429
PlumX Metrics