Gestational 3,3′,4,4′,5-Pentachlorobiphenyl (Pcb 126) Exposure Disrupts Fetoplacental Unit: Fetal Thyroid-Cytokines Dysfunction

Ahmed, R.G., A.W. El-Gareib, H.M. Shaker, 2018. Gestational 3,3′,4,4′,5-Pentachlorobiphenyl (Pcb 126) Exposure Disrupts Fetoplacental Unit: Fetal Thyroid-Cytokines Dysfunction. Life Sciences 192, 213–220. Doi: Https://Doi.Org/10.1016/J.Lfs.2017.11.033.

Posted: 2 Jul 2019

See all articles by Ahmed R. G.

Ahmed R. G.

Beni Suef University - Zoology Department

A. El-Gareib

Cairo University

H. M. Shaker

affiliation not provided to SSRN

Date Written: July 2, 2019

Abstract

Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40 μg/kg b. wt.) by oral gavage from gestation day (GD) 1 to 20. Potential effects of PCB 126 were evaluated by following the histopathological changes in the placenta by Haematoxylin and Eosin (H&E) stain and measuring the maternofetal thyroid axis (ELIZA), maternofetal body weight, and fetal growth markers (ELIZA), and cytokines (ELIZA) at embryonic day (ED) 20. Placental tissues of both treated groups showed hyperemia, hemorrhage, degeneration and apoptosis in labyrinth layer and spiral artery at GD 20. Both administrations of PCB 126 elevated serum thyrotropin (TSH) concentration, and decreased free thyroxine (FT4) and free triiodothyronine (FT3) concentrations, resulting in a maternofetal hypothyroidism. The presence of hypothyroidism increased fetal serum concentration of transforming growth factor-β (TGF-β), leptin (LEP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and decreased the fetal serum insulin growth factor-I (IGF-I), IGF-II, insulin, adiponectin (ADP), and growth hormone (GH) in both treated groups at ED 20. However, the increase in resistin (RETN) and interferon-γ (IFN-γ) was non-significant in low-dose group and highly significant in high-dose group. Simultaneously, the reduction in body weight of the dams and fetuses was observed in both PCB 126 groups of examined day with respect to the control group. The maternal PCB 126 distorted the fetoplacental unit might disrupt the fetal thyroid-cytokines axis and prenatal development.

Keywords: PCB 126, Fetoplacental unit, Thyroid, Cytokines, Pregnant, Fetuses

Suggested Citation

R. G., Ahmed and El-Gareib, A. and Shaker, H. M., Gestational 3,3′,4,4′,5-Pentachlorobiphenyl (Pcb 126) Exposure Disrupts Fetoplacental Unit: Fetal Thyroid-Cytokines Dysfunction (July 2, 2019). Ahmed, R.G., A.W. El-Gareib, H.M. Shaker, 2018. Gestational 3,3′,4,4′,5-Pentachlorobiphenyl (Pcb 126) Exposure Disrupts Fetoplacental Unit: Fetal Thyroid-Cytokines Dysfunction. Life Sciences 192, 213–220. Doi: Https://Doi.Org/10.1016/J.Lfs.2017.11.033., Available at SSRN: https://ssrn.com/abstract=3413402

Ahmed R. G. (Contact Author)

Beni Suef University - Zoology Department ( email )

Beni Suef
Egypt

A. El-Gareib

Cairo University

Orman
Giza, 12613
Egypt

H. M. Shaker

affiliation not provided to SSRN

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