A Novel Antibiotic-Like Substance Isolation from a Dermatophyte, Trichophyton rubrum

Reviews in Medical Microbiology 2018, DOI:10.1097/MRM.0000000000000129

Posted: 19 Aug 2019

See all articles by Adnan H. Aubaid

Adnan H. Aubaid

University of Al-Qadisiyah

Haider Alshawi

Al-Dewaniyah Technical Institute, Al-Furat Al-Awsat Technical University; Technical Institute of Al-Najaf,Al-Furat Al-Awsat Technical University

Nawfal H. Al-Dujailic

Al-Kufa University - Department of Biotechnology

Date Written: February 2018

Abstract

Secondary metabolites (SM) products permanently played an important role in medicine; fungi metabolites have increasingly become major players in recent pharmaceutical discovery in particular antimicrobial agents. The aim of study was to prepare and characterize of potential biological extract of culture filtrate of Trichophyton rubrum and tested as antibacterial, antioxidant agents. Local isolates of a dermatophyte T. rubrum were used and examined for production of SM. Extracts were checked for physical and chemical characterization using Fourier transform infrared spectrophotomete and HPLC and their cytotoxicity using a sensitive in-vitro brine shrimp lethality bioassay. The results revealed the isolation, preparation and characterization of different components of SM, included especially kojic acid, fusidic acid, amides and sulfones which gave antibacterial and antioxidant properties. In conclusion, the current study established the ability of a dermatophyte, T. rubrum to produce antibiotic-like substances, especially the sulfones which not isolated and recorded previously from T. rubrum.

Keywords: antimicrobial activity, antioxidant, secondary metabolites, Trichophyton rubrum

Suggested Citation

Aubaid, Adnan H. and Alshawi, Haider and Alshawi, Haider and Al-Dujailic, Nawfal H., A Novel Antibiotic-Like Substance Isolation from a Dermatophyte, Trichophyton rubrum (February 2018). Reviews in Medical Microbiology 2018, DOI:10.1097/MRM.0000000000000129, Available at SSRN: https://ssrn.com/abstract=3435486

Adnan H. Aubaid

University of Al-Qadisiyah

Diwaniyah
Iraq

Haider Alshawi (Contact Author)

Al-Dewaniyah Technical Institute, Al-Furat Al-Awsat Technical University ( email )

Al-Dewaniyah city 51009
Al-Dewaniyah, IA Al-Dewaniyah 00964
Iraq

HOME PAGE: http://idi.atu.edu.iq/

Technical Institute of Al-Najaf,Al-Furat Al-Awsat Technical University ( email )

Najaf -Manathera Street
Najaf -Iraq
Najaf, Najaf 54001
Iraq

HOME PAGE: http://https://inj.atu.edu.iq/

Nawfal H. Al-Dujailic

Al-Kufa University - Department of Biotechnology

Iraq

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