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Nasolacrimal Stent with Shape Memory as an Advanced Alternative to Silicone Products

33 Pages Posted: 27 Aug 2019 Publication Status: Accepted

See all articles by Ju Young Park

Ju Young Park

Yonsei University - Department of Medical Engineering

Jung Bok Lee

Yonsei University - Department of Medical Engineering

Woo Beom Shin

Yonsei University - Institute of Vision Research

Mi-Lan Kang

Yonsei University - Department of Medical Engineering; TMD Lab

Yong Cheol Shin

Yonsei University - Department of Medical Engineering

Deok Hyeon Son

Yonsei University - Department of Medical Engineering

Se Won Yi

TMD Lab

Jeong-Kee Yoon

Yonsei University - Department of Medical Engineering

Ji Young Kim

Yonsei University - Institute of Vision Research

Jae Sang Ko

Yonsei University - Institute of Vision Research

Chang Soo Kim

Yonsei University - Department of Medical Engineering

Jin Sook Yoon

Yonsei University - Institute of Vision Research

Hak-Joon Sung

Yonsei University - Department of Medical Engineering

Abstract

Epiphora is the overflow of tears typically caused by obstruction or occlusion of the nasolacrimal duct. Implantation of a silicone stent is the preferred treatment for epiphora; however, introducing a silicone stent into a narrow duct with complex geometry is challenging as it requires guidance by a sharp metal wire. Additionally, silicone can cause adverse reactions such as biofilm formation and tear flow resistance due to its extreme hydrophobicity. To overcome these problems, in this study we developed a new type of biocompatible shape memory polymer (SMP) stent with elasticity capacity for self-expansion. We demonstrate both in vitro and in vivo that the SMP stent is more efficient in terms of tear drainage capacity and exhibits greater resistance to biofilm formation than a silicone control, suggesting that it is a superior alternative to currently used materials for nasolacrimal stents.

Keywords: shape memory polymer, nasolacrimal stent, silicone, epiphora, biofilm

Suggested Citation

Park, Ju Young and Lee, Jung Bok and Shin, Woo Beom and Kang, Mi-Lan and Shin, Yong Cheol and Son, Deok Hyeon and Yi, Se Won and Yoon, Jeong-Kee and Kim, Ji Young and Ko, Jae Sang and Kim, Chang Soo and Yoon, Jin Sook and Sung, Hak-Joon, Nasolacrimal Stent with Shape Memory as an Advanced Alternative to Silicone Products. Available at SSRN: https://ssrn.com/abstract=3441970 or http://dx.doi.org/10.2139/ssrn.3441970

Ju Young Park (Contact Author)

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

Jung Bok Lee

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

Woo Beom Shin

Yonsei University - Institute of Vision Research

Korea, Republic of (South Korea)

Mi-Lan Kang

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

TMD Lab

Korea, Republic of (South Korea)

Yong Cheol Shin

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

Deok Hyeon Son

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

Se Won Yi

TMD Lab

Korea, Republic of (South Korea)

Jeong-Kee Yoon

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

Ji Young Kim

Yonsei University - Institute of Vision Research

Korea, Republic of (South Korea)

Jae Sang Ko

Yonsei University - Institute of Vision Research

Korea, Republic of (South Korea)

Chang Soo Kim

Yonsei University - Department of Medical Engineering ( email )

Korea, Republic of (South Korea)
033-760-2331 (Phone)
033-760-2918 (Fax)

HOME PAGE: http://www.yonseibiz.net/w_page/fix_ct/bbs/board.php?bo_table=fnr_db1

Jin Sook Yoon

Yonsei University - Institute of Vision Research

Korea, Republic of (South Korea)

Hak-Joon Sung

Yonsei University - Department of Medical Engineering

Korea, Republic of (South Korea)

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