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Waveguiding and Focusing in a Bio-Medium with an Optofluidic Cell Chain

32 Pages Posted: 26 Sep 2019 Publication Status: Accepted

See all articles by Tianli Wu

Tianli Wu

University of Jinan - Institute of Nanophotonics

Xixi Chen

University of Jinan - Institute of Nanophotonics

Zhiyong Gong

University of Jinan - Institute of Nanophotonics

Yuchao Li

University of Jinan - Institute of Nanophotonics

Yao Zhang

University of Jinan - Institute of Nanophotonics

Abstract

Long-distance waveguiding and submicron focusing of light in a bio-medium are crucial for biomedical sensing and imaging. Disordered bio-mediums usually exhibit high scattering and absorption, which limits effective waveguiding and focusing. Here, we demonstrate an optofluidic cell chain, assembled via an optical trapping force from an optical fiber probe, to achieve long-distance waveguiding and submicron light focusing in a disordered bio-medium. By applying a trapping light at 980 nm to generate an optical force, stable binding of E. faecalis cells was achieved in a fluid to assemble cell chains of different lengths. The length could reach up to 360 μm and the incident light (at 675, 532 and 473 nm) could be focused into a beam with a waist radius of 400 nm. As a potential practical application, backscattered signals from human red blood cells were detected using the cell chains, which is expected to benefit biomedical sensing and single cell analysis.

Keywords: bio-waveguide, biosensing, optical trapping, optofluidics, bio-medium

Suggested Citation

Wu, Tianli and Chen, Xixi and Gong, Zhiyong and Li, Yuchao and Zhang, Yao, Waveguiding and Focusing in a Bio-Medium with an Optofluidic Cell Chain. Available at SSRN: https://ssrn.com/abstract=3458143 or http://dx.doi.org/10.2139/ssrn.3458143

Tianli Wu (Contact Author)

University of Jinan - Institute of Nanophotonics

China

Xixi Chen

University of Jinan - Institute of Nanophotonics

China

Zhiyong Gong

University of Jinan - Institute of Nanophotonics

China

Yuchao Li

University of Jinan - Institute of Nanophotonics ( email )

China

Yao Zhang

University of Jinan - Institute of Nanophotonics ( email )

China

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