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A Novel GPCR-Based Memory Process is Necessary for the Influence of Predictive Learning on Choice

49 Pages Posted: 21 Oct 2019 Publication Status: Published

See all articles by Ashleigh Morse

Ashleigh Morse

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Beatrice Leung

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Emily Heath

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Jesus Bertran-Gonzalez

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Elise Pepin

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Billy Chieng

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Bernard Balleine

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Vincent Laurent

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

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Abstract

Predictive learning exerts a powerful influence over choice between instrumental actions. Nevertheless, how this learning is encoded in a sufficiently stable manner to influence choices that can occur much later in time is unclear. Here, we report that the basolateral amygdala (BLA) encodes predictive learning and establishes the memory necessary for future choices by driving the accumulation of delta-opioid receptors (DOPR) on the somatic membrane of cholinergic interneurons in the nucleus accumbens shell (NAc-S). We found that the BLA controls DOPR accumulation via its influence on substance P release in the NAc-S and that, although DOPR accumulation is not necessary for predictive learning per se, it is necessary for the influence of this learning on later choice between actions. This study uncovers, therefore, a novel GPCR-based form of memory that is established by predictive learning and is necessary for such learning to guide the selection and execution of specific actions.

Keywords: Predictive learning, Pavlovian-instrumental transfer, decision-making, nucleus accumbens, basolateral amygdala, cholinergic interneurons, delta-opioid receptors

Suggested Citation

Morse, Ashleigh and Leung, Beatrice and Heath, Emily and Bertran-Gonzalez, Jesus and Pepin, Elise and Chieng, Billy and Balleine, Bernard and Laurent, Vincent, A Novel GPCR-Based Memory Process is Necessary for the Influence of Predictive Learning on Choice (October 18, 2019). Available at SSRN: https://ssrn.com/abstract=3472044 or http://dx.doi.org/10.2139/ssrn.3472044
This version of the paper has not been formally peer reviewed.

Ashleigh Morse

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

Beatrice Leung

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

Emily Heath

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

Jesus Bertran-Gonzalez

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

Elise Pepin

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

Billy Chieng

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

Bernard Balleine (Contact Author)

University of New South Wales (UNSW) - Decision Neuroscience Laboratory ( email )

Australia

Vincent Laurent

University of New South Wales (UNSW) - Decision Neuroscience Laboratory

Australia

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