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Distinct Roles of Parvalbumin- and Somatostatin-Expressing Neurons in Flexible Representation of Task Variables in the Prefrontal Cortex

48 Pages Posted: 4 Dec 2019 Publication Status: Review Complete

See all articles by Huijeong Jeong

Huijeong Jeong

Korea Advanced Institute of Science and Technology (KAIST) - Department of Biological Sciences

Dohoung Kim

Institute for Basic Science (IBS) - Center for Synaptic Brain Dysfunctions

Min Song

Korea Advanced Institute of Science and Technology (KAIST) - Program of Brain and Cognitive Engineering

Se-Bum Paik

Korea Advanced Institute of Science and Technology (KAIST) - Program of Brain and Cognitive Engineering

Min Whan Jung

Korea Advanced Institute of Science and Technology (KAIST) - Department of Biological Sciences

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Abstract

A hallmark of the prefrontal cortex (PFC) is flexible representation of task-relevant variables. To investigate roles of different interneuron subtypes in this process, we examined discharge characteristics and inactivation effects of parvalbumin (PV)- and somatostatin (SOM)-expressing neurons in the mouse PFC during probabilistic classical conditioning. We found activity patterns and inactivation effects differed between PV and SOM neurons: SOM neurons conveyed cue-associated quantitative value signals until trial outcome, whereas PV neurons maintained valence signals even after trial outcome. Also, PV, but not SOM, neurons showed homogeneous bidirectional responses to reward and punishment. Moreover, inactivation of PV, but not SOM, neurons affected outcome responses and activity reversal of pyramidal neurons. Modeling suggested bidirectional outcome responses of PV neurons as an efficient mechanism for facilitating rapid cue-outcome contingency learning. Our results suggest primary roles of mPFC PV neurons in rapid value updating and SOM neurons in signaling values of upcoming events.

Keywords: Medial prefrontal cortex, flexibility, Inhibitory neuron, value, Classical Conditioning, mouse

Suggested Citation

Jeong, Huijeong and Kim, Dohoung and Song, Min and Paik, Se-Bum and Jung, Min Whan, Distinct Roles of Parvalbumin- and Somatostatin-Expressing Neurons in Flexible Representation of Task Variables in the Prefrontal Cortex (November 27, 2019). Available at SSRN: https://ssrn.com/abstract=3494378 or http://dx.doi.org/10.2139/ssrn.3494378
This version of the paper has not been formally peer reviewed.

Huijeong Jeong

Korea Advanced Institute of Science and Technology (KAIST) - Department of Biological Sciences ( email )

Daejeon, 34141
Korea, Republic of (South Korea)

Dohoung Kim

Institute for Basic Science (IBS) - Center for Synaptic Brain Dysfunctions ( email )

Korea, Republic of (South Korea)

Min Song

Korea Advanced Institute of Science and Technology (KAIST) - Program of Brain and Cognitive Engineering

Korea, Republic of (South Korea)

Se-Bum Paik

Korea Advanced Institute of Science and Technology (KAIST) - Program of Brain and Cognitive Engineering ( email )

Korea, Republic of (South Korea)

Min Whan Jung (Contact Author)

Korea Advanced Institute of Science and Technology (KAIST) - Department of Biological Sciences ( email )

Daejeon, 34141
Korea, Republic of (South Korea)

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