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Cell Migration Promotes the Functional Diversification of Gut Dendritic Cells

45 Pages Posted: 10 Dec 2019 Publication Status: Review Complete

See all articles by Violaine Randrian

Violaine Randrian

Institut Curie - Immunity & Cancer

Claudia A. Rivera

Institut Curie - Immunity & Cancer

Aleksandra Chikina

Institut Curie - Immunity & Cancer

Wilfrid Richer

Université Paris VI Pierre et Marie Curie - Laboratory of Translational Research in Pediatric Oncology

Sara M. Parigi

Karolinska Institutet - Division of Immunology and Allergy

Mathieu Maurin

Institut Curie - Immunity & Cancer

Christel Goudot

Institut Curie - Immunity & Cancer

Denis Krndija

University of Toulouse - Centre de Biologie Intégrative (CBI)

Paulo Czarnewski

Karolinska Institutet - Division of Immunology and Allergy

Sylvain Baulande

Institut Curie - Next generation Sequencing facility

Sonia Lameiras

Institut Curie - Next generation Sequencing facility

Julie Helft

Institut Curie - Immunity & Cancer

Pierre Guermonprez

King’s College London - Centre for Inflammation Biology and Cancer Immunology

Hélène D. Moreau

Institut Curie - Immunity & Cancer

Danijela Matic Vignjevic

PSL Research University - Institut Curie

Eduardo J. Villablanca

Karolinska Institutet - Division of Immunology and Allergy

Ana-Maria Lennon-Duménil

PSL Research University - INSERM U932 - Immunity and Cancer

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Abstract

Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population made of distinct subsets that express different markers and eventually display different functions. How cell-intrinsic programs and tissue-specific cues orchestrate DC diversification is only partially understood. By combining single-cell sequencing and intravital imaging, we here show that DC migration to the small intestine epithelium leads to the generation of an “immature-like” intraepithelial pool of cDC2s. These cells exhibit tolerogenic properties in contrast to lamina propria DCs, which are pro-inflammatory, resembling mature DCs. We further identify the actin motor myosin II and the nutrient-derived metabolite retinoic acid as the cell-intrinsic and -extrinsic cues driving the formation of this intraepithelial pool of cDC2s. Together, these results show that fine-tuning of DC migration controls their functional diversification within tissues.

Keywords: dendritic cells, small intestine, cell migration, epithelium, antigen presentation, T cell activation/anergy

Suggested Citation

Randrian, Violaine and Rivera, Claudia A. and Chikina, Aleksandra and Richer, Wilfrid and Parigi, Sara M. and Maurin, Mathieu and Goudot, Christel and Krndija, Denis and Czarnewski, Paulo and Baulande, Sylvain and Lameiras, Sonia and Helft, Julie and Guermonprez, Pierre and Moreau, Hélène D. and Vignjevic, Danijela Matic and Villablanca, Eduardo J. and Lennon-Duménil, Ana-Maria, Cell Migration Promotes the Functional Diversification of Gut Dendritic Cells (November 5, 2019). Available at SSRN: https://ssrn.com/abstract=3499176 or http://dx.doi.org/10.2139/ssrn.3499176
This version of the paper has not been formally peer reviewed.

Violaine Randrian

Institut Curie - Immunity & Cancer ( email )

France

Claudia A. Rivera

Institut Curie - Immunity & Cancer ( email )

France

Aleksandra Chikina

Institut Curie - Immunity & Cancer ( email )

France

Wilfrid Richer

Université Paris VI Pierre et Marie Curie - Laboratory of Translational Research in Pediatric Oncology

75248 Paris Cedex 5
France

Sara M. Parigi

Karolinska Institutet - Division of Immunology and Allergy ( email )

Sweden

Mathieu Maurin

Institut Curie - Immunity & Cancer

France

Christel Goudot

Institut Curie - Immunity & Cancer ( email )

France

Denis Krndija

University of Toulouse - Centre de Biologie Intégrative (CBI) ( email )

France

Paulo Czarnewski

Karolinska Institutet - Division of Immunology and Allergy ( email )

Sweden

Sylvain Baulande

Institut Curie - Next generation Sequencing facility ( email )

France

Sonia Lameiras

Institut Curie - Next generation Sequencing facility ( email )

France

Julie Helft

Institut Curie - Immunity & Cancer ( email )

France

Pierre Guermonprez

King’s College London - Centre for Inflammation Biology and Cancer Immunology ( email )

Strand
London, WC2R 2LS
United Kingdom

Hélène D. Moreau

Institut Curie - Immunity & Cancer

France

Danijela Matic Vignjevic

PSL Research University - Institut Curie ( email )

26 rue d'Ulm
Paris cedex 05
Paris, 75248
France

Eduardo J. Villablanca

Karolinska Institutet - Division of Immunology and Allergy ( email )

Sweden

Ana-Maria Lennon-Duménil (Contact Author)

PSL Research University - INSERM U932 - Immunity and Cancer ( email )

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