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cAMP-Dependent Co-Stabilization of Axonal Arbors from Adjacent Developing Neurons

33 Pages Posted: 10 Jan 2020 Publication Status: Published

See all articles by Alice Louail

Alice Louail

Sorbonne Université - Institut de la Vision

Martijn Sierksma

Sorbonne University - Institut de la Vision

Antoine Chaffiol

Sorbonne University - Institut de la Vision

Ahlem Assali

Medical University of South Carolina - Department of Neurosciences

Sandrine Couvet

Sorbonne Université - Institut de la Vision

Melissa Nedjam

Sorbonne University - Institut de la Vision

Fiona Roche

Sorbonne Université - Institut de la Vision

Yvrick Zagar

Sorbonne Université - Institut de la Vision

Jens Duebel

Sorbonne University - Institut de la Vision

Xavier Nicol

Sorbonne Université - Institut de la Vision

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Abstract

Axonal arbors in many neuronal networks are exuberant early during development and become refined by activity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactions between co-active axons to co-stabilize their connections, but the demonstration of such interactions is lacking. Here we provide experimental evidence that reducing cAMP signaling in a subset of retinal ganglion cells favors the elimination of thalamic projections from neighboring neurons, pointing to a cAMP-dependent interaction that promotes axon stabilization.

Keywords: competition, cooperation, retina, pruning, retinal ganglion cells, spontaneous activity, dorso-lateral geniculate nucleus, axon

Suggested Citation

Louail, Alice and Sierksma, Martijn Christiaan and Chaffiol, Antoine and Assali, Ahlem and Couvet, Sandrine and Nedjam, Melissa and Roche, Fiona and Zagar, Yvrick and Duebel, Jens and Nicol, Xavier, cAMP-Dependent Co-Stabilization of Axonal Arbors from Adjacent Developing Neurons. Available at SSRN: https://ssrn.com/abstract=3516894 or http://dx.doi.org/10.2139/ssrn.3516894
This version of the paper has not been formally peer reviewed.

Alice Louail

Sorbonne Université - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Martijn Christiaan Sierksma

Sorbonne University - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Antoine Chaffiol

Sorbonne University - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Ahlem Assali

Medical University of South Carolina - Department of Neurosciences ( email )

United States

Sandrine Couvet

Sorbonne Université - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Melissa Nedjam

Sorbonne University - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Fiona Roche

Sorbonne Université - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Yvrick Zagar

Sorbonne Université - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Jens Duebel

Sorbonne University - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

Xavier Nicol (Contact Author)

Sorbonne Université - Institut de la Vision ( email )

17 rue Moreau
Paris, 75012
France

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