Axonal arbors in many neuronal networks are exuberant early during development and become refined by activity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactions between co-active axons to co-stabilize their connections, but the demonstration of such interactions is lacking. Here we provide experimental evidence that reducing cAMP signaling in a subset of retinal ganglion cells favors the elimination of thalamic projections from neighboring neurons, pointing to a cAMP-dependent interaction that promotes axon stabilization.
Louail, Alice and Sierksma, Martijn Christiaan and Chaffiol, Antoine and Assali, Ahlem and Couvet, Sandrine and Nedjam, Melissa and Roche, Fiona and Zagar, Yvrick and Duebel, Jens and Nicol, Xavier, cAMP-Dependent Co-Stabilization of Axonal Arbors from Adjacent Developing Neurons. Available at SSRN: https://ssrn.com/abstract=3516894 or http://dx.doi.org/10.2139/ssrn.3516894
This version of the paper has not been formally peer reviewed.
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