lancet-header

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.

Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China

26 Pages Posted: 27 Jan 2020

See all articles by Nanshan Chen

Nanshan Chen

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

Min Zhou

Shanghai Jiao Tong University (SJTU)

Xuan Dong

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

Jie-ming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine

Fengyun Gong

Huazhong University of Science and Technology - Wuhan Jinyintan Hospital

Yang Han

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Yang Qiu

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Jingli Wang

Huazhong University of Science and Technology - Wuhan Jinyintan Hospital

Ying Liu

Huazhong University of Science and Technology - Wuhan Jinyintan Hospital

Yuan Wei

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

Jia'an Xia

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

Ting Yu

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

Xinxin Zhang

Shanghai Jiao Tong University (SJTU) - Research Laboratory of Clinical Virology

Li Zhang

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

More...

Abstract

Background: Since December 2019, a novel coronavirus (2019-nCoV) associated pneumonia has emerged in Wuhan, China. The study aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.

Methods: 99 cases admitted to Wuhan Jinyintan Hospital during January 1 to 20, 2020 and confirmed by real-time reverse-transcriptase polymerase-chain-reaction (RT-PCR) test were analyzed for epidemiological, demographic, clinical, radiological features, and laboratory data.

Findings: Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the South China Seafood Wholesale Market. The average age of the patients was 62.85 ± 11.99 years, including 67 males and 32 females. 2019-nCoV was detected in all patients by RT-PCR, and some of them also by serological testing, and metagenomics sequencing analysis. 50 cases (50.51%) had chronic basic diseases. Patients had clinical manifestations of fever (83%), cough (82%), shortness of breath (31%), muscle aches (11%), headache (8%), fuzzy confusion (7%), chest pain (2%), and diarrhea (2%). According to imaging examination, 74 patients showed bilateral pneumonia (74.75%), 25 patients showed multiple mottled and ground-glass opacity, and 1 patient had pneumothorax. Most patients received antiviral, antibiotics, supportive treatments, continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO), and had good prognosis. 17 patients developed acute Respiratory Distress Syndrome (ARDS) and among them, 2 patients worsened in a short period of time and died of multiple organ failure.

Interpretation: The infection of the 2019-nCoV can result in severe and even fatal respiratory disease like ARDS. It is very important to actively prevent complications and secondary infections, treat underlying diseases, and provide timely organ function support. Early diagnosis, early isolation, multiple treatment, and intervention of CRRT and ECMO when necessary can effectively reduce mortality caused by severe coronavirus pneumonia.

Funding: National Key R&D Program of China (No. 2017YFC1309700)

Declaration of Interest: The author reports no conflicts of interest in this work.

Ethical Approval: The study was approved by Jinyintan Hospital Ethics Committee and written informed consent was obtained from all patients involved before enrolment.

Keywords: novel coronavirus; 2019-nCoV pneumonia; diagnosis; treatment

Suggested Citation

Chen, Nanshan and Zhou, Min and Dong, Xuan and Qu, Jie-ming and Gong, Fengyun and Han, Yang and Qiu, Yang and Wang, Jingli and Liu, Ying and Wei, Yuan and Xia, Jia'an and Yu, Ting and Zhang, Xinxin and Zhang, Li, Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China (1/21/2020). Available at SSRN: https://ssrn.com/abstract=3523861 or http://dx.doi.org/10.2139/ssrn.3523861

Nanshan Chen

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory ( email )

China

Min Zhou

Shanghai Jiao Tong University (SJTU)

KoGuan Law School
Shanghai 200030, Shanghai 200052
China

Xuan Dong

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory ( email )

China

Jie-ming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine ( email )

China

Fengyun Gong

Huazhong University of Science and Technology - Wuhan Jinyintan Hospital

China

Yang Han

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Wuhan, 430071
China

Yang Qiu

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Wuhan, 430071
China

Jingli Wang

Huazhong University of Science and Technology - Wuhan Jinyintan Hospital

China

Ying Liu

Huazhong University of Science and Technology - Wuhan Jinyintan Hospital

China

Yuan Wei

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

China

Jia'an Xia

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

China

Ting Yu

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory

China

Xinxin Zhang

Shanghai Jiao Tong University (SJTU) - Research Laboratory of Clinical Virology ( email )

Ruijin Er Road 197
Shanghai, 200025
China

Li Zhang (Contact Author)

Huazhong University of Science and Technology - Department of Tuberculosis and Respiratory ( email )

China