Cell Wall Composition of the Riboflavin Over Producer Eremotheciumashbyii

8 Pages Posted: 7 Feb 2020

Date Written: January 30, 2020

Abstract

Eremothecium ashbyii is a filamentous hemiascomycete fungus very closely related to the yeast, Saccharomyces cerevisiae and is a natural overproducer of riboflavin (vitamin B2). An interesting observation is that the riboflavin accumulation is not uniform in all the hyphal cells. Some cells accumulate more than others and some cells do not accumulate riboflavin at all suggesting some kind of regulation at the subcellular level/ developmental level. Riboflavin is not toxic to humans but for fungi and yeast it is toxic, causing cytotoxicity of the cells, damaging DNA, RNA and proteins. Considering the cytotoxic effect, the overproduction of riboflavin by Eremothecium ashbyii raises many questions. The main question is, whether riboflavin overproducers benefit from this property. Cell walls are essential to fungal growth and survival. The rigidity of the fungal cell well determines the shape of the fungal cell and also provides protection from many environmental stresses. Recent studies have revealed that the fungal cell wall plays a regulatory role in response to positive and negative environmental stimuli. In the case of Eremothecium ashbyii significant lacunae exist in our understanding of cellular processes such as vesicle trafficking, cytoskeletal organization and its regulation. These processes are vital with regard to riboflavin production and secretion. Hence the work reported here was undertaken with an aim to gain a preliminary understanding of the cell wall composition of Eremothecium ashbyii and thus gain a better insight into its development and how it affects riboflavin synthesis/storage/ transport.

Keywords: hemiascomycetes, cytoskeletal organization, vesicle trafficking

Suggested Citation

Das, Simadri and V, Vidhya and Subramaniam, Vijayalakshmi, Cell Wall Composition of the Riboflavin Over Producer Eremotheciumashbyii (January 30, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020, Available at SSRN: https://ssrn.com/abstract=3528006 or http://dx.doi.org/10.2139/ssrn.3528006

Simadri Das (Contact Author)

Vels University ( email )

P.V, Vaithiyalingam Street
Pallavaram
Chennai, Tamil Nadu 600117
India
600117 (Fax)

Vidhya V

Vels University ( email )

P.V, Vaithiyalingam Street
Pallavaram
Chennai, Tamil Nadu 600117
India
600117 (Fax)

Vijayalakshmi Subramaniam

Vels University ( email )

P.V, Vaithiyalingam Street
Pallavaram
Chennai, Tamil Nadu 600117
India

Do you have negative results from your research you’d like to share?

Paper statistics

Downloads
60
Abstract Views
379
Rank
643,103
PlumX Metrics