Synthesis and Characterization Some of Cyanopyridine, Cyanopyrans From 4′-Trifluromethyacetophenyl, 4′-Trifluromethoxyacetophenyl Derivative and Their Antimicrobial Activity
Posted: 3 Feb 2020
Date Written: January 30, 2020
Abstract
Infectious diseases are one of the frequent issues encountered globally. Even though there are numerous of drugs on available in the market for the treatment of infectious diseases, still many new molecules are required due to their unwanted reaction with the current drugs. Hence, chalcones of collection prepared (A, B 1-10) containing 4’-trifluromethyacetophenyl and 4’-trifluromethoxyacetophenyl moieties with the aid of Claisen-Schmidt condensation reaction. These chalcones were subjected to Michael elimination to give 2-amino-3- cyanopyridine (AC, BC 1-10) in presence of malonitrile and ammonium acetate, These chalcones were subjected to Michael addition to give 2-amino-3- cyanopyrans (AD, BD 1-10) in presence of malonitrile and Pyridine. All the compounds had been characterised by IR, NMR, Mass spectroscopy and elemental analysis. The compounds had been further screened for antibacterial and antifungal activities by using cup plate method towards chosen bacterial and fungal organisms. The compound B3C displayed potent anti-microbial activity, whereas the compound A3C showed superior antibacterial and antifungal activities. Concluded that antimicrobial activity order as follows Cyanpyridine, chalcones, cyanopyrans. This study helped to identify novel Cyanpyridine and cyanopyrans from 4’-trifluromethyacetophenyl and 4’-trifluromethoxyacetophenyl derivative against anti-microbial activity.
Keywords: 4’-trifluromethyacetophenyl chalcones, 4’-trifluromethoxyacetophenyl chalcones, 2-amino-3- cyanopyridine Compounds, 2-amino-3- cyanopyrans Compound
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