Synthesis and Characterization Some of Cyanopyridine, Cyanopyrans From 4′-Trifluromethyacetophenyl, 4′-Trifluromethoxyacetophenyl Derivative and Their Antimicrobial Activity

Posted: 3 Feb 2020

See all articles by Surendra Babu Lagu

Surendra Babu Lagu

Andhra University

Rajendra Prasad Yejella

ANDHRA UNIVERSITY

Deepthi Doddigopu

Pharmaceutical chemistry

Afzal Shaik

Vignan Pharmacy College

Jagadish B

Andhra University

Harish G

Andhra University

Date Written: January 30, 2020

Abstract

Infectious diseases are one of the frequent issues encountered globally. Even though there are numerous of drugs on available in the market for the treatment of infectious diseases, still many new molecules are required due to their unwanted reaction with the current drugs. Hence, chalcones of collection prepared (A, B 1-10) containing 4’-trifluromethyacetophenyl and 4’-trifluromethoxyacetophenyl moieties with the aid of Claisen-Schmidt condensation reaction. These chalcones were subjected to Michael elimination to give 2-amino-3- cyanopyridine (AC, BC 1-10) in presence of malonitrile and ammonium acetate, These chalcones were subjected to Michael addition to give 2-amino-3- cyanopyrans (AD, BD 1-10) in presence of malonitrile and Pyridine. All the compounds had been characterised by IR, NMR, Mass spectroscopy and elemental analysis. The compounds had been further screened for antibacterial and antifungal activities by using cup plate method towards chosen bacterial and fungal organisms. The compound B3C displayed potent anti-microbial activity, whereas the compound A3C showed superior antibacterial and antifungal activities. Concluded that antimicrobial activity order as follows Cyanpyridine, chalcones, cyanopyrans. This study helped to identify novel Cyanpyridine and cyanopyrans from 4’-trifluromethyacetophenyl and 4’-trifluromethoxyacetophenyl derivative against anti-microbial activity.

Keywords: 4’-trifluromethyacetophenyl chalcones, 4’-trifluromethoxyacetophenyl chalcones, 2-amino-3- cyanopyridine Compounds, 2-amino-3- cyanopyrans Compound

Suggested Citation

Lagu, Surendra Babu and Yejella, Rajendra Prasad and Doddigopu, Deepthi and Shaik, Afzal and B, Jagadish and G, Harish, Synthesis and Characterization Some of Cyanopyridine, Cyanopyrans From 4′-Trifluromethyacetophenyl, 4′-Trifluromethoxyacetophenyl Derivative and Their Antimicrobial Activity (January 30, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020, Available at SSRN: https://ssrn.com/abstract=3528178

Surendra Babu Lagu (Contact Author)

Andhra University ( email )

Visakhapatnam
Visakhapatnam, 530003
India
08341405043 (Phone)
530003 (Fax)

Rajendra Prasad Yejella

ANDHRA UNIVERSITY ( email )

Visakhapatnam, Andhra Pradesh
India

Deepthi Doddigopu

Pharmaceutical chemistry ( email )

Visakhapatnam, Andhra Pradesh
India
08341405043 (Phone)
530003 (Fax)

Afzal Shaik

Vignan Pharmacy College ( email )

VADLAMUDI
GUNTUR, AK Andhra Pradesh 522213
India
00919966014374 (Phone)

Jagadish B

Andhra University ( email )

Andhra University
Visakhapatnam, Andhra Pradesh 530003
India

Harish G

Andhra University ( email )

Visakhapatnam
Visakhapatnam, 530003
India

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