To Development and Validation Spectrophotometric Estimation of Vildagliptin Through Oxidative Coupling Reaction Using MBTH Reagent in Pharmaceutical Dosage Form

Posted: 13 Feb 2020

See all articles by Vaishali Patel

Vaishali Patel

Parul institute of pharmacy and research,Parul university

Divya Desai

Parul University - Parul Institute of Pharmacy and Research

Prachi Parmar

Parul University - Parul Institute of Pharmacy and Research

Krishna Bhatt

Parul University - Parul Institute of Pharmacy and Research

Rakshita Patel

Parul University - Parul Institute of Pharmacy and Research

Mrunali Shah

Parul University - Parul Institute of Pharmacy and Research

Dharti Patil

Parul University - Parul Institute of Pharmacy and Research

Date Written: February 5, 2020

Abstract

Scientifically estimation of Vildagliptin in bulk and pharmaceutical dosage forms by 3-methyl-2-bezothiazoline hydrazone reagent using longer wavelength give strong absorbance. The purpose of this analytical validation procedure is to validate using ICH guideline.3-methyl-2-bezothiazoline hydrazone reacts with ferric chloride in the presence of amine group, Resulting green coloured species scanned in uv-visible spectrophotometric with the range 400-800 nm. Linearity concentration ranges 10 to 50 μg/ml and it given absorbance at 620 nm, Correlation coefficient value 0.998, Recovery studies obtain within range of 98.41 to 99.75% at maximum absorbance 620 nm. This method can be successfully applied for the estimation of drug content in pharmaceutical formulations. Resulting Analytical Validate method suitable for its intended use.

Keywords: 3-methyl-2-benzothiazoline hydrazone, Vildagliptin, Ferric chloride spectrophotometric determination, ICH guidelines

Suggested Citation

Patel, Vaishali and Desai, Divya and Parmar, Prachi and Bhatt, Krishna and Patel, Rakshita and Shah, Mrunali and Patil, Dharti, To Development and Validation Spectrophotometric Estimation of Vildagliptin Through Oxidative Coupling Reaction Using MBTH Reagent in Pharmaceutical Dosage Form (February 5, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020, Available at SSRN: https://ssrn.com/abstract=3532255

Vaishali Patel

Parul institute of pharmacy and research,Parul university ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

Divya Desai

Parul University - Parul Institute of Pharmacy and Research ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

Prachi Parmar

Parul University - Parul Institute of Pharmacy and Research ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

Krishna Bhatt (Contact Author)

Parul University - Parul Institute of Pharmacy and Research ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

Rakshita Patel

Parul University - Parul Institute of Pharmacy and Research ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

Mrunali Shah

Parul University - Parul Institute of Pharmacy and Research ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

Dharti Patil

Parul University - Parul Institute of Pharmacy and Research ( email )

Waghodia Road
Vadodara, Gujarat 390019
India

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