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Interleukin-6 as a Potential Biomarker of COVID-19 Progression

Médecine et Maladies Infectieuses, DOI: 10.1016/j.medmal.2020.04.002

Posted: 30 Mar 2020 Last revised: 7 Apr 2020

See all articles by Zulvikar Syambani Ulhaq

Zulvikar Syambani Ulhaq

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang

Gita Vita Soraya

Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar

Date Written: March 18, 2020

Abstract

The rapid transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in the pandemic of Coronavirus Disease 2019 (COVID-19), affecting over 372.757 people worldwide. An increasing proportion of cases manifest as severe disease, characterised by respiratory disfunction and multi-organ failure. Previous studies have suggested the mechanisms of cytokine storm as a cause for progression and have measured associations between IL-6 levels and COVID-19 fatality. In this meta-analysis, we aimed to perform an evidence-based investigation on the role of IL-6 measurement to predict disease progression. Our results indicate that IL-6 may be important in identifying disease progression among COVID-19 infected patients.

Note: Funding: None.

Conflict of Interest: None to declare.

Keywords: SARS-CoV-2, COVID-19, Novel Coronavirus, IL-6, prognosis

Suggested Citation

Ulhaq, Zulvikar Syambani and Soraya, Gita Vita, Interleukin-6 as a Potential Biomarker of COVID-19 Progression (March 18, 2020). Médecine et Maladies Infectieuses, DOI: 10.1016/j.medmal.2020.04.002, Available at SSRN: https://ssrn.com/abstract=3562887 or http://dx.doi.org/10.2139/ssrn.3562887

Zulvikar Syambani Ulhaq

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang ( email )

Jl. Gajayana No.50
Malang, East Java

Gita Vita Soraya (Contact Author)

Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar ( email )

Jl Perintis Kemerdekaan km 10
Makassar, South Sulawesi 90245
Indonesia

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