STUDY OF THE TOXICOLOGICAL CHARACTERISTICS OF WATER-SOLUBLE SURFACE-ACTIVE SUBSTANCES OBTAINED BASED ON PHENOL, FORMALDEHYDE AND SODIUM SULPHITE

Sokolenko, N., Ruban, E., Ostrovka, V., Oleksiy, M., Popov, Y., Sedych, A. (2020). Study of the toxicological characteristics of water-soluble surface-active substances obtained based on phenol, formaldehyde and sodium sulphite. Technology Audit and Production Reserves, 1 (3 (51)), 44–47.

4 Pages Posted: 6 Oct 2020

See all articles by Nadiia Sokolenko

Nadiia Sokolenko

Volodymyr Dahl East Ukrainian National University - Institute of Chemical Technologies

Elina Ruban

affiliation not provided to SSRN

Victor Ostrovka

affiliation not provided to SSRN

Moroz Oleksiy

affiliation not provided to SSRN

Yevgeniy Popov

affiliation not provided to SSRN

Anna Sedych

affiliation not provided to SSRN

Date Written: February 28, 2020

Abstract

The object of research is the products of the condensation reaction of phenol, formaldehyde and sodium sulfite in an aqueous medium, in order to obtain water-soluble non-toxic products based on it, which can be proposed for use as surfactants. In the course of the study, the effect of the reaction conditions (ratio of components, temperature and process time) on the quality of the products obtained and their toxicological characteristics are studied. The optimal ratio of the starting reagents phenol: formaldehyde: sodium sulfite: water is selected, which allows to obtain a product with surface-active properties and which contains substances that can be harmful to health. It is recommended that the condensation process be carried out within 1 hour, the optimum reaction temperature is selected at 130 °C. The qualitative characteristics of the obtained product allow to recommend its use as an anionic surfactant. For this, the symptomatic and toxicological properties of the newly developed surfactant, the product of the condensation of phenol, formaldehyde and sodium sulfite in an aqueous medium, are studied. Based on the studies, it is found that with the introduction of such surfactants into the stomach of experimental white rats-females, their slightly irritating effect on the mucous membranes and skin is observed. According to the mortality criterion, with a single oral administration (LD50), the harmful effects of the substance on rats are not noted. According to the research results, the product can be attributed to class IV hazard (low hazard substances) according to GOST 12.1.007.

According to toxicological findings, the resulting product can be recommended for use as a textile auxiliary substance, in the technological operations of bleaching, dyeing and printing of fabrics in contact with human skin, as well as additives to concrete mixtures used in the construction industry and other industries.

Keywords: condensation product of phenol; formaldehyde and sodium sulphite; surfactants; toxicology; lethal dose

Suggested Citation

Sokolenko, Nadiia and Ruban, Elina and Ostrovka, Victor and Oleksiy, Moroz and Popov, Yevgeniy and Sedych, Anna, STUDY OF THE TOXICOLOGICAL CHARACTERISTICS OF WATER-SOLUBLE SURFACE-ACTIVE SUBSTANCES OBTAINED BASED ON PHENOL, FORMALDEHYDE AND SODIUM SULPHITE (February 28, 2020). Sokolenko, N., Ruban, E., Ostrovka, V., Oleksiy, M., Popov, Y., Sedych, A. (2020). Study of the toxicological characteristics of water-soluble surface-active substances obtained based on phenol, formaldehyde and sodium sulphite. Technology Audit and Production Reserves, 1 (3 (51)), 44–47., Available at SSRN: https://ssrn.com/abstract=3676202

Nadiia Sokolenko (Contact Author)

Volodymyr Dahl East Ukrainian National University - Institute of Chemical Technologies ( email )

Vladimirska str., 31
Rubizhne, Lugansk region,, 93009
Ukraine

Elina Ruban

affiliation not provided to SSRN

Victor Ostrovka

affiliation not provided to SSRN

Moroz Oleksiy

affiliation not provided to SSRN

Yevgeniy Popov

affiliation not provided to SSRN

Anna Sedych

affiliation not provided to SSRN

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