Search for Natural Alkaloids As SARS-CoV-2 Proteas and RdRp Inhibitors: A Docking-Based Study

Abstract

To find an immediately applicable drug for the treatment of COVID-19 positive patients, a plausible life cycle of this virus is proposed from the analysis of a few case reports. Based on this proposal and symptomatic similarities, a few common drug-molecules are tested as a protease inhibitor and RNA-dependent RNA polymarase (RdRp) inhibitor of the SARS-CoV-2 virus using the COVID-19 Docking Server. It is observed that anisotine and vasicoline of Justicia adhatoda and Pemirolast are very good inhibitors. As all these three compounds are market available drugs, an immediate clinical trial is plausible which may lead to the golden success against the present pandemic. We prescribed different drugs for different purposes and stages of viral infection.

Note: Funding: None to declare.

Declaration of Interests: None to declare.

Keywords: COVID-19, Structure of SARS-CoV-2, Infection mechanism of COVID-19, Model drugs for COVID-19, Docking study

JEL Classification: z0