lancet-header

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.

Effectiveness of Convalescent Plasma Therapy in Indian Patients with COVID-19

19 Pages Posted: 23 Nov 2020

See all articles by Sandeep Budhiraja

Sandeep Budhiraja

Max Super Specialty Hospital - Max Healthcare

Arun Dewan

Critical Care, Max Healthcare

Ritesh Aggarwal

Critical Care, Max Healthcare

Omender Singh

Critical Care, Max Healthcare

Deven Juneja

Critical Care, Max Healthcare

Sangeeta Pathak

Transfusion Medicine, Max Healthcare

Yogendra Pal Singh

Critical Care, Max Healthcare

Ajay Gupta

Critical Care, Max Healthcare

Reeta Rai

Transfusion Medicine, Max Healthcare

Abhaya Indrayan

Max Healthcare

vinitaa Jha

Clinical Directorate, Max Healthcare

Rahul Naithani

Hematology & Bone Marrow Transplant Division, Max Healthcare

More...

Abstract

Background: Convalescent plasma (CP) is being used as a treatment option in hospitalized patients with COVID-19. Till date, there is conflicting evidence on efficacy of CP in reducing COVID-19 related mortality.Objective: to evaluate the effect of CP on 28-day mortality reduction in patients with COVID-19.

Methods: We did a multi-center, retrospective case control observational study from 1st May 2020 to 31st August 2020.  A total of 1079 adult patients with moderate and severe COVID-19 requiring oxygen, were reviewed. Of these, 694 patients were admitted to ICU. Out of these, 333 were given CP along with best supportive care and remaining 361 received best supportive care only.

Results: In the overall group of 1079 patients, mortality in plasma vs no plasma group was statistically not significant (22.4% vs 18.5%; p = 0.125). However, in patients with COVID-19 admitted to ICU, mortality was significantly lower in plasma group (25.5% vs 33.2%; p = 0.026). This benefit of reduced mortality was most seen in age group 60 to 74 years (26.7% vs 43.0%; p = 0.004), driven mostly by females of this age group (23.1% vs 53.5%; p = 0.013). Significant difference in mortality was observed in patients with one comorbidity (22.3% vs 36.5%; p = 0.004). Moreover, patients on ventilator had significantly lower mortality in the plasma arm (37.2% vs 49.3%; p = 0.009); particularly so for patients on invasive mechanical ventilation (63.9% vs 82.9%; p = 0.014).

Conclusion:  The use of CP reduced mortality in COVID-19 elderly patients admitted in ICU, above 60 years of age, particularly females, those with comorbidities and especially those who required some form of ventilation.

Funding Statement: None to declare.

Declaration of Interests: None to declare.

Ethics Approval Statement: The manuscript has ethical clearance and approval from the ethics committee of the institute . A copy of the approval letter is attached. (Reference number is
RS/MSSH/GMRCHS/IEC/IM/20-16).

Keywords: Convalescent plasma therapy, COVID-19, ICU cases, Mortality, Subgroup analysis

Suggested Citation

Budhiraja, Sandeep and Dewan, Arun and Aggarwal, Ritesh and Singh, Omender and Juneja, Deven and Pathak, Sangeeta and Singh, Yogendra Pal and Gupta, Ajay and Rai, Reeta and Indrayan, Abhaya and Jha, vinitaa and Naithani, Rahul, Effectiveness of Convalescent Plasma Therapy in Indian Patients with COVID-19. Available at SSRN: https://ssrn.com/abstract=3726179 or http://dx.doi.org/10.2139/ssrn.3726179

Sandeep Budhiraja (Contact Author)

Max Super Specialty Hospital - Max Healthcare ( email )

India

Arun Dewan

Critical Care, Max Healthcare ( email )

Ritesh Aggarwal

Critical Care, Max Healthcare

Omender Singh

Critical Care, Max Healthcare ( email )

Deven Juneja

Critical Care, Max Healthcare ( email )

Sangeeta Pathak

Transfusion Medicine, Max Healthcare ( email )

Yogendra Pal Singh

Critical Care, Max Healthcare ( email )

Ajay Gupta

Critical Care, Max Healthcare

Reeta Rai

Transfusion Medicine, Max Healthcare ( email )

Abhaya Indrayan

Max Healthcare ( email )

India
9810315030 (Phone)

HOME PAGE: http://https://indrayan.weebly.com

Vinitaa Jha

Clinical Directorate, Max Healthcare ( email )

Rahul Naithani

Hematology & Bone Marrow Transplant Division, Max Healthcare ( email )

Click here to go to TheLancet.com

Paper statistics

Downloads
265
Abstract Views
2,442
PlumX Metrics