One-Step Synthesis of Copper-Platinum Nanoparticles Modified Electrode for Non-Enzymatic Salivary Glucose Detection

Abstract

Fabricating modified electrodes with facile and environment-friendly strategy is of great importance for glucose detection and electrodes based on nanoparticles are research hotspots at present. Here, copper-platinum nanoparticles (Cu-Pt NPs) were successfully modified on glassy carbon electrode (GCE) for non-enzymatic glucose detection by a facile co-electrodeposition process. A binder-free electrode was constructed by the direct in-situ electrodeposition method, which could accelerate the transfer rate of electrons on the surface of electrode, and there was no need for any additional assistant reagent during electrodeposition process. Moreover, bimetallic Cu-Pt promoted the catalytic capability towards glucose oxidation for the synergistic effect. The Cu-Pt NPs/GCE displayed a high sensitivity of 2209 µA mM -1 cm -2 in a linear range of 10-750 µM and a low limit of detection (LOD) of 1.8 µM (S/N=3). The Cu-Pt NPs/GCE possessed plenty of advantages containing marvelous selectivity, superb reproducibility, sterling long-term stability and rapid response time. Notably, the capability towards glucose detection could be renewed to a satisfactory level through an unsophisticated reduction processing program. The designed Cu-Pt NPs/GCE showed its potential applying in the enzyme-free glucose detection of saliva samples.

Keywords: electrochemical sensor, glucose detection, Copper-platinum nanoparticles, In-situ co-electrodeposition