Novel Synthesis of Bicalutamide Drug Substance and their Impurities using Imidazolium Type of Ionic Liquid

Abstract

The chemical and pharmaceutical industry is under an accelerating pressure to find environmentally friendly organic reaction methodologies. Owing to the unique advantages of ionic liquids, the preparation and industrial applications of ionic liquids have attracted considerable interest. Herein we report novel synthesis of imidazolium based Room-Temperature Ionic Liquid (RTIL) using cheaper reagents which have been used for the synthesis of Antiandrogenic and Antineoplastic drug Bicalutamide and its impurities reported in US pharmacopoeia.

Keywords: anti-androgen, bicalutamide, casodex, impurities, room temperature ionic liquids (RTIL)