Pd-Catalyzed Heteroannulation of Isoxazoles: Convergent Synthesis of Isoxazolo[5,4-C]Quinolines

Abstract

Variously substituted isoxazolo[5,4- c ]quinolines can be easily prepared in high yields by Pd-catalyzed heteroannulation of 5-carbonyl-4-haloisoxazoles with 2-aminophenylboronic acid derivatives.

Keywords: Heteroannulation, Isoxazoles, Isoxazolo[5, 4-c]quinolines, 2-Aminophenylboronic acid, Pd-Catalyzed Cross-Coupling